233-36-3Relevant articles and documents
Pyrrolo(iso)quinoline derivatives as 5-HT2C receptor agonists
Adams, David R.,Bentley, Jonathan M.,Benwell, Karen R.,Bickerdike, Michael J.,Bodkin, Corinna D.,Cliffe, Ian A.,Dourish, Colin T.,George, Ashley R.,Kennett, Guy A.,Knight, Antony R.,Malcolm, Craig S.,Mansell, Howard L.,Misra, Anil,Quirk, Kathleen,Roffey, Jonathan R.A.,Vickers, Steven P.
, p. 677 - 680 (2006)
A series of 1-(1-pyrrolo(iso)quinolinyl)-2-propylamines was synthesised and evaluated as 5-HT2C receptor agonists for the treatment of obesity. The general methods of synthesis of the precursor indoles are described. The functional efficacy and
Microwave assisted Leimgruber-Batcho reaction for the preparation of indoles, azaindoles and pyrroylquinolines
Siu, Jason,Baxendale, Ian R.,Ley, Steven V.
, p. 160 - 167 (2007/10/03)
The development of enhanced conditions for Lewis acid catalysed Leimgruber-Batcho indole synthesis using microwave acceleration is described. This approach has permitted the preparation of a variety of heteroaromatic enamine intermediates in good yield and high purities. Subsequent catalytic hydrogenation reactions, under various conditions including the use of a solid-phase encapsulated catalyst, furnish the corresponding indole derivatives in good yields.
The reaction of vinyl Grignard reagents with 2-substituted nitroarenes: A new approach to the synthesis of 7-substituted indoles
Bartoli,Palmieri,Bosco,Dalpozzo
, p. 2129 - 2132 (2007/10/02)
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