91004-60-3Relevant articles and documents
The synthesis of 4-(3,3-dimethyl-3H-pyrrolo[2,3-f] quinolin-2-yl)pyrazoles and 4-(3,3-dimethyl-3H-pyrrolo[3,2-h] quinolin-2-yl)pyrazoles
Rashidi,Afghan,Baradarani, Mehdi M.,Jouleb, John A.
body text, p. 428 - 431 (2009/09/25)
(Chemical Equation Presented) 5-Hydrazinoquinoline and 8-hydrazinoquinoline were converted via Fischer syntheses with 3-methylbutan-2-one into pyrido-indolenines 2,3,3-trimethyl-3H-pyrrolo[2,3-f]quinoline 7 and 2,3,3-trimethyl-3H-pyrrolo[ 3,2-h]quinoline 11, respectively. Exposure of the indolenines to the Vilsmeier reagent produced aminomethylene-malondialdehydes 8 and 12, which reacted with hydrazine or arylhydrazines to give 4-(3H-pyrrolo[2,3-f]quinolin-2-yl)- and 4-(3H-pyrrolo[3,2-h]quinolin-2-yl)- pyrazoles, 9 and 13.
ACYLHYDRAZIDE P2X7 ANTAGONISTS AND USES THEREOF
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Page/Page column 42-43, (2008/06/13)
The present invention discloses a compound of formula (I) or a pharmaceutically acceptable salt or prodrug thereof, wherein D, A, m, n, Rx and Ry are defined in the description. The present invention also relates to pharmaceutical compositions of compound
Preparation of sodium-hydrogen exchanger type-1 inhibitors
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, (2008/06/13)
This invention relates to methods of preparing sodium-hydrogen exchanger type 1 (NHE-1) inhibitors of formula I′ 1intermediates of the NHE-1 inhibitors and a new almost colorless form of the NHE-1 inhibitor N-(5-cyclopropyl-1-quinolin-5-yl-1H-pyrazole-4-carbonyl)-guanidine.