23328-62-3Relevant articles and documents
Photoinduced electron transfer, decarboxylation, and radical fragmentation of cysteine derivatives: A chemically induced dynamic nuclear polarization study
Goez, Martin,Rozwadowski, Jaroslaw,Marciniak, Bronislaw
, p. 2882 - 2891 (1996)
The photoreactions of cysteine derivatives I with 4-carboxybenzophenone in D2O were investigated by measurements of chemically induced dynamic nuclear polarization (CIDNP). The quenching mechanism is electron transfer from sulfur at every pH; even if the amino group of I is deprotonated, electron transfer from nitrogen does not participate. Decarboxylation of I?+ to give α-aminoalkyl radicals V? occurs on the CIDNP time scale and causes strong cooperative effects. The decarboxylation rate is increased significantly by deprotonation of the amino function; this is due to product control. V? decays by two competing pathways. Fragmentation of the Cβ - S bond in V? yields vinylamine, which is hydrolyzed to acetaldehyde at pH ? 7.25, and thiyl radicals, which then attack the sensitizer to give combination products. Oxidation of V? by ground-state sensitizer leads to sulfur-containing aldehydes or other products, depending on pH. Relative rates of fragmentation and oxidation were determined from CIDNP signal intensities. From the temperature dependence of the polarizations, the activation energy of β-fragmentation was estimated to be 54 kJ mol-1.
USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND COMPOSITIONS COMPRISING SUCH ACTIVE INGREDIENTS
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Paragraph 0383; 0388; 0398, (2020/07/07)
The invention relates primarily to a method of modulation, preferably of in vitro and/or in vivo modulation, of the cold menthol receptor TRPM8, wherein the receptor is contacted with at least one modulator selected from the group consisting of the compounds of the structure type 1 described herein. The present invention further relates to corresponding uses and compositions comprising such compounds.
Studies on umami taste. Synthesis of new guanosine 5′-phosphate derivatives and their synergistic effect with monosodium glutamate
Cairoli, Paola,Morelli, Carlo F.,Speranza, Giovanna,Manitto, Paolo,Pieraccini, Stefano,Sironi, Maurizio
supporting information; experimental part, p. 1043 - 1050 (2009/05/08)
A number of N2-alkyl and N2-acyl derivatives of guanosine 5′-phosphate (GMP) have been synthesized and tested for their synergistic effect with monosodium L-glutamate (MSG), the prototypical substance imparting umami taste to savory-based foods. Capacities to enhance the taste intensity of MSG (γ values) were estimated through subjective comparisons of MSG/nucleotide mixtures in water with appropriate solutions of MSG alone. Assuming β = γ[nucleotide]/γ[IMP], β values of the N 2-substituted GMPs were found in the range 1.2-5.7. Such values appear to be related to the chain length of the substituent in the 2-position of the purine nucleus and dependent on the replacement of a CH2 group with an S atom and/or with an α-CO group. These findings indicate that the exocyclic NHR group of the guanine moiety is actively implicated in the synergism between GMP derivatives and MSG. Theoretical calculations suggest that an anti conformation is probably assumed by ribonucleotide molecules interacting with umami receptors.
TRICYCLIC DELTA OPIOID MODULATORS
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Page 47-48; 83, (2008/06/13)
The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
