234108-73-7 Usage
Description
4-AMINO-2-CHLOROPYRIDINE, N-BOC PROTECTED 98, also known as tert-Butyl (2-Chloropyridin-4-yl)carbamate, is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceuticals and bioactive molecules. Its unique chemical structure, featuring a chlorinated pyridine ring and a protected amino group, makes it a versatile building block in the development of novel therapeutic agents.
Uses
Used in Pharmaceutical Industry:
4-AMINO-2-CHLOROPYRIDINE, N-BOC PROTECTED 98 is used as a reactant for the preparation of inter-domain stabilizers for allosteric Akt inhibitors. Akt, also known as protein kinase B, is a serine/threonine-specific protein kinase that plays a critical role in cellular survival, growth, and angiogenesis. Inhibition of Akt has been shown to have potential therapeutic benefits in various diseases, including cancer, making it an important target for drug development.
Akt Inhibitors:
4-AMINO-2-CHLOROPYRIDINE, N-BOC PROTECTED 98 is used as a key component in the synthesis of inter-domain stabilizers for allosteric Akt inhibitors. These inhibitors modulate the activity of Akt by binding to a specific site on the protein, leading to a conformational change that prevents its activation. This, in turn, disrupts the signaling pathways involved in cell survival and proliferation, making it a promising approach for the treatment of cancer and other diseases associated with aberrant Akt activity.
Drug Development:
In addition to its role in the synthesis of Akt inhibitors, 4-AMINO-2-CHLOROPYRIDINE, N-BOC PROTECTED 98 can also be utilized in the development of other bioactive molecules and pharmaceuticals. Its unique chemical structure allows for further functionalization and modification, enabling the creation of novel compounds with potential applications in various therapeutic areas.
Research and Development:
4-AMINO-2-CHLOROPYRIDINE, N-BOC PROTECTED 98 is also used as a valuable research tool in the field of medicinal chemistry. Its availability and reactivity make it an attractive candidate for the synthesis of new compounds and the exploration of novel chemical reactions. This contributes to the ongoing efforts in drug discovery and the development of innovative therapeutic strategies to address unmet medical needs.
Check Digit Verification of cas no
The CAS Registry Mumber 234108-73-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,3,4,1,0 and 8 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 234108-73:
(8*2)+(7*3)+(6*4)+(5*1)+(4*0)+(3*8)+(2*7)+(1*3)=107
107 % 10 = 7
So 234108-73-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H13ClN2O2/c1-10(2,3)15-9(14)13-7-4-5-12-8(11)6-7/h4-6H,1-3H3,(H,12,13,14)
234108-73-7Relevant articles and documents
Selective palladium-catalysed amination of 4-chloropyridines with benzylamines using the Josiphos ligand
Hawkins, Janet L.,Gregson, Clare L.,Hassall, Lorraine A.,Holmes, Jane L.
, p. 6734 - 6737 (2014)
A synthetic strategy for the synthesis of a library of 4-N-benzylamino-2-N-phenyl-pyridines is herein described. The approach involves a Pd-assisted cross-coupling of a 4-chloro-N-phenylpyridin-2-amine intermediate with a range of benzylamines. A variety of ligands were screened, the most successful being the Josiphos ligand, which gave the desired products in good to moderate yields. The reactions occur quickly, within 30 min, with full conversion of the intermediate into the desired product.
Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt
Uhlenbrock, Niklas,Smith, Steven,Weisner, J?rn,Landel, Ina,Lindemann, Marius,Le, Thien Anh,Hardick, Julia,Gontla, Rajesh,Scheinpflug, Rebekka,Czodrowski, Paul,Janning, Petra,Depta, Laura,Quambusch, Lena,Müller, Matthias P.,Engels, Bernd,Rauh, Daniel
, p. 3573 - 3585 (2019/03/28)
The Ser/Thr kinase Akt (Protein Kinase B/PKB) is a master switch in cellular signal transduction pathways. Its downstream signaling influences cell proliferation, cell growth, and apoptosis, rendering Akt a prominent drug target. The unique activation mechanism of Akt involves a change of the relative orientation of its N-terminal pleckstrin homology (PH) and the kinase domain and makes this kinase suitable for highly specific allosteric modulation. Here we present a unique set of crystal structures of covalent-allosteric interdomain inhibitors in complex with full-length Akt and report the structure-based design, synthesis, biological and pharmacological evaluation of a focused library of these innovative inhibitors.
Rearrangement of N,N-di-tert-butoxycarbonylpyridin-4-amines and formation of polyfunctional pyridines
Liu, Yahua,Ding, Qiang,Wu, Xu
, p. 6025 - 6028 (2008/12/21)
(Chemical Equation Presented) N,N-Di-tert-butoxycarbonylpyridin-4-amines were found to be rearranged to tert-butyl 4-(tert-butoxycarbonylamino) nicotinates by treatment with LDA in THF.
