234108-74-8

Basic information

• Product Name: CarbaMic acid, (2-chloro-3-iodo-4-pyridinyl)-, 1,1-diMethylethyl ester (9CI)
• Synonyms: CarbaMic acid, (2-chloro-3-iodo-4-pyridinyl)-, 1,1-diMethylethyl ester (9CI);(2-chloro-3-iodo-4-pyridinyl)Carbamic acid 1,1-dimethylethyl ester;(2-chloro-3-iodo-4-pyridinyl)Carbamic acid 1,1-dimethylethyl este
• CAS NO: 234108-74-8
• Molecular Formula: C₁₀H₁₂ClIN₂O₂
• Molecular Weight: 354.57195
• Mol File: 234108-74-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 341.805°C at 760 mmHg
• Flash Point: 160.518°C
• Appearance: /
• Density: 1.724g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.618
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 11.18±0.70(Predicted)
• CAS DataBase Reference: CarbaMic acid, (2-chloro-3-iodo-4-pyridinyl)-, 1,1-diMethylethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: CarbaMic acid, (2-chloro-3-iodo-4-pyridinyl)-, 1,1-diMethylethyl ester (9CI)(234108-74-8)
• EPA Substance Registry System: CarbaMic acid, (2-chloro-3-iodo-4-pyridinyl)-, 1,1-diMethylethyl ester (9CI)(234108-74-8)

Safety Data

• Hazardous Substances Data: 234108-74-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H12ClIN2O2/c1-10(2,3)16-9(15)14-6-4-5-13-8(11)7(6)12/h4-5H,1-3H3,(H,13,14,15)

Upstream product

• 234108-73-7 (2-chloro-pyridin-4-yl)-carbamic acid tert-butyl ester 
• 14432-12-3 4-Amino-2-chloropyridine 
• 909036-46-0 2-chloro-3-iodo-pyridin-4-ylamine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 34619-03-9 tert-butyldicarbonate 

Downstream Products

• 854018-87-4 4-chloro-2-methyl-1H-pyrrolo[3,2-c]pyridine 
• 1415043-75-2 {2-Methyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetic acid 
• 1415043-76-3 Ethyl {2-methyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate 
• 1415043-77-4 Ethyl {2,5-dimethyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate 
• 1415043-78-5 {2,5-Dimethyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetic acid 
• 1415043-79-6 Ethyl {5-(difluoromethyl)-2-methyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate 
• 1415043-80-9 {5-(Difluoromethyl)-2-methyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetic acid 
• 1415043-03-6 4-Chloro-2-methyl-3-[2-(phenylsulfonyl)benzyl]-1H-pyrrolo[3,2-c]pyridine 
• 1415043-04-7 ethyl {4-chloro-2-methyl-3-[2-(phenylsulfonyl)benzyl]-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate 
• 1420070-44-5 ethyl {4-chloro-3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-2-methyl-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate 
• 1420070-45-6 ethyl {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-2,4-dimethyl-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate 
• 1420071-10-8 {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-2,4-dimethyl-1H-pyrrolo[3,2-c]pyridin-1-yl}acetic acid 
• 1439394-42-9 2-methoxy-3-(2-phenylethynyl)pyridine-4-amine 
• 1439394-44-1 4-iodo-2-methoxy-3-(2-phenylethynyl)pyridine 

Relevant articles and documents

NEW CRTH2 ANTAGONISTS

The present invention relates to compounds of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by CRTh2 antagonist activity.

BICYCLIC HETEROARYL DERIVATIVES AS KINASE INHIBITORS

The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula 1: wherein Het, X, R1 and R2 are as defined herein.

PYRROLOPYRIDINE DERIVATIVES AND USE THEREOF FOR TREATING DISEASES MEDIATED BY PROSTAGLANDIN D2 (PGD2)

Compounds of formula (Ia) or (Ib): or pharmaceutically acceptable salts, hydrates, solvates, complexes or prodrugs thereof are useful in the treatment of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis.