2351-88-4Relevant articles and documents
TARGETING GLI PROTEINS IN HUMAN CANCER BY SMALL MOLECULES
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Paragraph 00239, (2014/08/07)
The present disclosure provides compositions, pharmaceutical preparations and methods for the diagnosis and treatment of cancers expressing a GLI polypeptide. The disclosed compositions and pharmaceutical preparations may comprise one or more pyrazolyl-containing compounds, or an analog or derivative thereof.
A practical, efficient, and atom economic alternative to the Wittig and Horner-Wadsworth-Emmons reactions for the synthesis of (E)-α,β- unsaturated esters from aldehydes
List, Benjamin,Doehring, Arno,Hechavarria Fonseca, Maria T.,Job, Andreas,Rios Torres, Ramon
, p. 476 - 482 (2007/10/03)
We describe a highly efficient new methodology for the synthesis of (E)-α,β-unsaturated esters from aldehydes. In our DMAP-catalyzed reaction, both aromatic as well as aliphatic aldehydes furnish the desired products highly regio- and stereoselectively if treated with commercially available or synthetically easily accessible malonic acid half ester. A large scale application in the synthesis of p-methoxycinnamates, which are of use as sunscreen ingredients, is described.
In situ oxidative diol cleavage - Wittig processes
Outram, Helen S.,Raw, Steven A.,Taylor, Richard J.K.
, p. 6185 - 6187 (2007/10/03)
1,2-Diol cleavage followed by in situ trapping of the resulting aldehyde with a stabilised phosphorane is described; both manganese dioxide and silica-supported sodium periodate can be used as the heterogeneous oxidant, but the latter reagent is generally the most efficient.
