311-46-6 Usage
Description
Ethyl dimethylphosphonoacetate is an organic compound that serves as a versatile reagent in the synthesis of various pharmaceutical compounds and other organic molecules. It is characterized by its phosphonoacetate structure, which allows for a range of chemical reactions and applications in different industries.
Uses
Used in Pharmaceutical Industry:
Ethyl dimethylphosphonoacetate is used as a reactant for the synthesis of non-nucleoside inhibitors of HCV polymerase NS5B, which are essential in the development of antiviral drugs targeting Hepatitis C virus.
Used in Neuropeptide Y1 Receptor Antagonists:
Ethyl dimethylphosphonoacetate is utilized as a key building block in the synthesis of neuropeptide Y1 receptor antagonists, which have potential applications in the treatment of obesity, anxiety, and other conditions related to the neuropeptide Y system.
Used in Organic Synthesis:
Ethyl dimethylphosphonoacetate is used as a reactant in Horner-Wadsworth-Emmons reactions, which are widely employed in the preparation of alkenylcarboxylates, a class of compounds with various applications in the chemical and pharmaceutical industries.
Used in Enantioselective Transfer Hydrogenation:
Ethyl dimethylphosphonoacetate serves as a reactant in enantioselective transfer hydrogenation reactions, which are crucial for the preparation of the C7-C14 fragment of ulapualide A, a potent antifungal and anthelmintic agent.
Used in Intramolecular Michael Reactions:
Ethyl dimethylphosphonoacetate is used as a reactant in intramolecular Michael reactions, which are important for the synthesis of complex organic molecules with specific structural features.
Used in Olefination of Peptidyl Aldehydes:
Ethyl dimethylphosphonoacetate is employed as a reactant in the olefination of peptidyl aldehydes with stabilized ylides, a reaction that is essential for the synthesis of various peptide-derived compounds with potential biological activities.
Check Digit Verification of cas no
The CAS Registry Mumber 311-46-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,1 and 1 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 311-46:
(5*3)+(4*1)+(3*1)+(2*4)+(1*6)=36
36 % 10 = 6
So 311-46-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H13O5P/c1-4-11-5(7)6(2,3)12(8,9)10/h4H2,1-3H3,(H2,8,9,10)
311-46-6Relevant articles and documents
Alkyl phosphonate preparing method
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Paragraph 0068; 0069; 0070; 0071, (2017/10/07)
The invention provides an alkyl phosphonate preparing method. The method comprises: performing an Arbuzov reaction on compound A and compound B in a continuous reaction apparatus, and continuously discharging the product obtained from the reaction from the continuous reaction apparatus during the reaction procedure, to obtain alkyl phosphonate. The reaction temperature in the reaction procedure is T1; either of compound A and compound B having a lower boiling point has a boiling point at a standard atmosphere pressure to be T2; T1 is higher than T2 by 10-40 DEG C; and the reaction pressure in the reaction procedure is 0.5-2.0 MPa. The preparing method in the invention may use halohydrocarbon having large steric hindrance and lower polarizability of carbon-halogen bond as compound A, thereby effectively expanding a selection range of substrate, and correspondingly expanding the types of alkyl phosphonate prepared by using the Arbuzov reaction.
A facile synthesis of novel chiral phosphonoacetates bearing a stereogenic phosphorus atom
Sano, Shigeki,Kujime, Eiko,Takemoto, Yuka,Shiro, Motoo,Nagao, Yoshimitsu
, p. 131 - 134 (2007/10/03)
Novel chiral phosphonoacetates bearing a stereogenic phosphorus atom were successfully synthesized by enzyme-catalyzed kinetic resolution of racemic phosphonoacetates.
Intramolecular cyclopropanation reactions en route to novel P- heterocycles
Hanson, Paul R.,Sprott, Kevin T.,Wrobleski, Aaron D.
, p. 1455 - 1458 (2007/10/03)
The first examples of intramolecular cyclopropanation reactions on a phosphonate template catalyzed by Rh2(OAc)4 are described. These reactions proceed in excellent yield and give mixtures of the P-heterocycles cis-2a-d and trans-2a-d with moderate levels of diastereoselectivity. The diastereoselectivity of this transformation is dependent upon the size of the alkyl group R contained in the alkyl α-diazodiallylphosphonoacetate starting materials 1a-d.
