57749-86-7Relevant articles and documents
Synthesis and biological evaluation of cajanonic acid A derivatives as potential PPARγ antagonists
Guo, Bing,Hu, Chu-Jiao,Peng, Jin-Gang,Tang, Lei,Wang, Jian-Ta,Xia, Jing,Zhang, Ji-Quan,Zhu, Gao-Feng
supporting information, (2021/10/22)
Four series of cajanonic acid A (CAA) derivatives have been designed and synthesized. The newly prepared compounds have been screened for glucose consumption activity in HepG2 cell lines and PPARγ antagonistic activity in HEK293 cell lines. Compound 26g bearing a tetrahydroisoquinolinone scaffold showed the most potent PPARγ antagonistic and hypoglycemic activities. An oral glucose tolerance test (OGTT) was performed and the results further confirmed that 26g was a potent hypoglycemic agent. In addition, the possible binding modes for compound 26g in the PPARγ protein have been investigated in this study.
LiCl-Promoted Pd(ii)-catalyzed ortho carbonylation of N,N- dimethylbenzylamines
Li, Hu,Cai, Gui-Xin,Shi, Zhang-Jie
, p. 10442 - 10446 (2011/01/08)
Palladium-catalyzed highly regioselective carbonylation of substituted N,N-dimethylbenzylamines with the assistance of LiCl was developed. The ortho-functionalized N,N-dimethylbenzylamine was further transformed into ortho-methyl benzoate under mild conditions. These two transformations could be combined into one pot to produce the desired product in moderate yield. Applications of this methodology to synthesize the fragments of variolaric acid were also studied.
Total synthesis of CRM646-A and -B, two fungal glucuronides with potent heparinase inhibition activities
Wang, Ping,Zhang, Zhaojun,Yu, Biao
, p. 8884 - 8889 (2007/10/03)
CRM646-A (1) and -B (2), two fungal glucuronides with a dimeric 2,4-dihydroxy-6-alkylbenzoic acid (orcinol p-depside) aglycone showing significant heparinase and telomerase inhibition activities, were synthesized for the first time. The successful approac