23930-29-2 Usage
Description
3α,11β-Dihydroxy-5α-pregnan-20-one, also known as Allopregnanolone, is a naturally occurring neurosteroid and a metabolite of progesterone. It is derived from cholesterol and plays a significant role in various physiological processes, including the modulation of the central nervous system and the maintenance of pregnancy. Allopregnanolone exhibits immunomodulatory properties and is classified as a female sex steroid.
Uses
Used in Pharmaceutical Applications:
3α,11β-Dihydroxy-5α-pregnan-20-one is used as a therapeutic agent for various neurological and psychiatric disorders due to its anxiolytic, sedative, and neuroprotective effects. It modulates the function of the gamma-aminobutyric acid (GABA) receptors, which are crucial for inhibiting neuronal excitability and maintaining a balanced nervous system.
Used in Obstetrics and Gynecology:
In the field of obstetrics and gynecology, 3α,11β-Dihydroxy-5α-pregnan-20-one is used as a hormone supplement to support the maintenance of pregnancy. Its immunomodulatory properties help in preventing miscarriages and ensuring a healthy gestational period.
Used in Research:
3α,11β-Dihydroxy-5α-pregnan-20-one is also utilized as a research tool for studying the effects of neurosteroids on the central nervous system, as well as their potential role in the development and treatment of various neurological and psychiatric conditions.
Used in Drug Delivery Systems:
Similar to gallotannin, novel drug delivery systems can be developed for 3α,11β-Dihydroxy-5α-pregnan-20-one to enhance its bioavailability, delivery, and therapeutic outcomes in treating neurological and psychiatric disorders. Various organic and metallic nanoparticles can be employed as carriers for the efficient delivery of this neurosteroid.
Check Digit Verification of cas no
The CAS Registry Mumber 23930-29-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,9,3 and 0 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 23930-29:
(7*2)+(6*3)+(5*9)+(4*3)+(3*0)+(2*2)+(1*9)=102
102 % 10 = 2
So 23930-29-2 is a valid CAS Registry Number.
23930-29-2Relevant articles and documents
Allopregnanolone and pregnanolone analogues modified in the C ring: Synthesis and activity
Slavíková, Barbora,Bujons, Jordi,Matyá?, Libor,Vidal, Miguel,Babot, Zoila,Kri?tofíková, Zdena,Su?ol, Cristina,Kasal, Alexander
, p. 2323 - 2336 (2013/06/04)
(25R)-3β-Hydroxy-5α-spirostan-12-one (hecogenin) and 11α-hydroxypregn-4-ene-3,20-dione (11α-hydroxyprogesterone) were used as starting materials for the synthesis of a series of 11- and 12-substituted derivatives of 5ξ-pregnanolone (3α-hydroxy-5α- pregnan-20-one and 3α-hydroxy-5β-pregnan-20-one), the principal neurosteroid acting via γ-aminobutyric acid (GABA). These analogues were designed to study the structural requirements of the corresponding GABA A receptor. Their biological activity was measured by in vitro test with [3H]flunitrazepam as radioligand in which allopregnanolone and its active analogues stimulated the binding to the GABAA receptor. Analysis of the SAR data suggests dependence of the flunitrazepam binding activity on the hydrophobic-hydrophilic balance of the groups at the C-ring edge rather than on specific interactions between them and the receptor.
