23930-19-0 Usage
Originator
Althesin ,Glaxo ,UK ,1972
Uses
Anesthetic;nociception blocker
Manufacturing Process
A solution of 3α-hydroxy-5α-pregn-16-ene-11,20-dione (200 mg) in freshly
distilled tetrahydrofuran (8 ml) with 5% palladium on carbon (100 ml) was
hydrogenated until hydrogen uptake ceased. The mixture was filtered through
a pad of kieselguhr and the tetrahydrofuran removed in vacuum to give 196
mg, MP 171°C to 172°C.
Therapeutic Function
Anesthetic component
Biological Activity
A neurosteroid anesthetic that directly activates and potentiates GABA A receptor-activated membrane current (I GABA ). Efficacy but not potency is determined by the alpha subunit of the receptor (EC 50 values are 1.4, 1.8, 2.1, 2.4 and 2.5 μ M for α 1 β 1 γ 3, α 1 β 1 γ 1, β 1 γ 1, α 2 β 1 γ 2L and α 1 β 1 γ 2L isoforms respectively).
Check Digit Verification of cas no
The CAS Registry Mumber 23930-19-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,9,3 and 0 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 23930-19:
(7*2)+(6*3)+(5*9)+(4*3)+(3*0)+(2*1)+(1*9)=100
100 % 10 = 0
So 23930-19-0 is a valid CAS Registry Number.
InChI:InChI=1/C21H32O3/c1-12(22)16-6-7-17-15-5-4-13-10-14(23)8-9-20(13,2)19(15)18(24)11-21(16,17)3/h13-17,19,23H,4-11H2,1-3H3/t13-,14+,15-,16+,17-,19+,20-,21+/m0/s1
23930-19-0Relevant articles and documents
NEUROACTIVE STEROIDS AND METHODS OF PREPARATION
-
, (2020/01/31)
Disclosed are neuroactive steroid anaesthetic agents, methods for their preparation and compositions comprising the same. The invention provides scaled up and/or GMP methods for preparing neuroactive steroids, such as alfaxalone, alfadolone and alfadolone acetate.
First synthesis of a C-homosteroid from pregn-4-ene-3,11,20-trione
Zhang, Zonglei,Wang, Lizhong,Bian, Xiaoqin,Sun, Qian,Xu, Hangxian,Wang, Cunde
, p. 98 - 104 (2011/03/17)
(3α,5α)-3-Hydroxy-C-homopregnane-11,20-dione (3) was prepared in eleven steps from the commercially available pregn-4-ene-3,11,20-trione (4) via the 11-oxo-13-formyl-12,13-secopregnane intermediate 11 (Scheme 2). Subjection of this secopregnane to an intramolecular aldol condensation afforded the α,β-unsaturated key intermediate C-homopregn-12-en-11-one 12. Copyright