239482-65-6

Basic information

• Product Name: 1,3'-bis(tert-butoxycarbonyl)-1-(4-chlorobenzyl)-2-methyl-2-thiopseudourea
• Synonyms: 1,3'-bis(tert-butoxycarbonyl)-1-(4-chlorobenzyl)-2-methyl-2-thiopseudourea
• CAS NO: 239482-65-6
• Molecular Weight: 414.953
• Mol File: 239482-65-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1,3'-bis(tert-butoxycarbonyl)-1-(4-chlorobenzyl)-2-methyl-2-thiopseudourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3'-bis(tert-butoxycarbonyl)-1-(4-chlorobenzyl)-2-methyl-2-thiopseudourea(239482-65-6)
• EPA Substance Registry System: 1,3'-bis(tert-butoxycarbonyl)-1-(4-chlorobenzyl)-2-methyl-2-thiopseudourea(239482-65-6)

Safety Data

• Hazardous Substances Data: 239482-65-6(Hazardous Substances Data)

Upstream product

• 622-95-7 4-chlorobenzyl bromide 
• 322474-21-5 N,N'-bis-Boc-S-methyl-isothiourea 

Downstream Products

• 239482-66-7 N,N'-bis(tert-butoxycarbonyl)-N'-(4-chlorobenzyl)-N''-(3-pyrrolidin-1-ylpropyl)guanidine 

Relevant articles and documents

Design, synthesis, and structure-activity relationships of novel non- imidazole histamine H3 receptor antagonists

Novel, potent, and selective non-imidazole histamine H3 receptor antagonists have been prepared based on the low-affinity ligand dimaprit (pK(I) 7.32 ± 0.12, pK(B) 5.93 ± 0.17). Detailed structure-activity studies have revealed that N-(4-chlorobenzyl)-N-(6-pyrrolidin-1-ylhexyl)guanidine (pK(I) 8.38 ± 0.21, pK(B) 8.39 ± 0.13), 30, and N-(4-chlorobenzyl)-N-(7- pyrrolidin-1-ylheptyl)guanidine (pK(I) 8.78 ± 0.12, pK(B) 8.38 ± 0.10), 31, exhibit high affinity for the histamine H3 receptor. Antagonists 30 and 31 demonstrate significant selectivity over the other histamine, H1 and H2, receptor subtypes and a 100-fold selectivity in the σ1 binding assay. Compounds 30 and 31 are the most potent, selective non-imidazole histamine H3 receptor antagonists reported in the literature to date.