23985-58-2

Basic information

• Product Name: Benzenepropanoic acid, b-hydroxy-a-methyl-
• CAS NO: 23985-58-2
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• Mol File: 23985-58-2.mol
• Article Data: 23

Chemical Properties

• CAS DataBase Reference: Benzenepropanoic acid, b-hydroxy-a-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, b-hydroxy-a-methyl-(23985-58-2)
• EPA Substance Registry System: Benzenepropanoic acid, b-hydroxy-a-methyl-(23985-58-2)

Safety Data

• Hazardous Substances Data: 23985-58-2(Hazardous Substances Data)

Upstream product

• 3279-26-3 methyl dichlorophosphite 
• 79-03-8 propionyl chloride 
• 100-52-7 benzaldehyde 
• 145124-75-0 (S)-N-(1-methylethyl)-4-amino-2-butanol 
• 17226-79-8 methyl 3-hydroxy-2-methyl-3-phenylpropanoate 
• 31469-22-4 1,1-bis(trimethylsilyloxy)prop-1-ene 
• 6531-45-9 lithium propanoate 
• 802294-64-0 propionic acid 
• 90290-37-2 (2S,3R)-1-((2S,5S)-2,5-Bis-methoxymethoxymethyl-pyrrolidin-1-yl)-3-hydroxy-2-methyl-3-phenyl-propan-1-one 
• 89337-61-1 tert-butyl((1-methoxyprop-1-en-1-yl)oxy)dimethylsilane 
• 36482-33-4 (2RS,3SR)-3-hydroxy-2-methyl-3-phenyl-propionic acid hydrazide 
• 93440-92-7 threo-4-Hydroxy-3-methyl-2-oxo-4-phenylbutansaeure (Kaliumsalz) 
• 122230-00-6 3-Hydroxy-2-methyl-3-phenyl-1-tripropylsilanyl-propan-1-one 
• 122229-96-3 1-(tert-Butyl-dimethyl-silanyl)-3-hydroxy-2-methyl-3-phenyl-propan-1-one 

Downstream Products

• 17226-79-8 methyl 3-hydroxy-2-methyl-3-phenylpropanoate 
• 116126-02-4 (+)-(2S,3R)-3-hydroxy-2-methyl-3-phenylpropanoic acid 
• 94199-26-5 (2S,3R)-methyl 3-hydroxy-2-methyl-3-phenylpropionate 
• 76549-03-6 methyl (2S,3S)-3-hydroxy-2-methyl-3-phenylpropanoate 
• 76549-05-8 methyl (2R,3R)-3-hydroxy-2-methyl-3-phenylpropanoate 
• 36041-80-2 (2R,3S)-methyl 3-hydroxy-2-methyl-3-phenylpropanoate 
• 7087-77-6 (1S,2S) /(1R,2R)-2-methyl-1-phenylpropane-1,3-diol 
• 71155-82-3 3-hydroxy-2-methyl-3-phenylpropan-3-olide 
• 99056-06-1 C₁₀H₁₁N₃O₂ 
• 36391-82-9 5r-methyl-6t-phenyl-[1,3]oxazinan-2-one 
• 36393-58-5 anti-3-hydroxy-2-methyl-3-phenylpropanylamine 
• 29478-51-1 (2RS,3SR)-3-hydroxy-2-methyl-3-phenylpropionamide 
• 76943-97-0 (2SR,3RS)-N-(3-hydroxy-2-methyl-3-phenylpropionyl)pyrrolidine 
• 637-50-3 1-phenylpropene 

Relevant articles and documents

Asymmetric Diels-Alder, Michael, and aldol reactions using a planar chiral 1,3-oxazol-2(3H)-one derived from (R)-(+)-4-hydroxy-[2.2]paracyclophane

(+)-(R)-[2.2]Paracyclophane[4,5-d]-1,3-oxazol-2(3H)-one exhibiting planar chirality has been used as a chiral auxiliary in asymmetric Diels-Alder, Michael, and aldol reactions of α,β-unsaturated carboxy and enolate imides, respectively. The endo-exo- and face-diastereoselectivity is good and is controlled by the spatial relationship between the prochiral center and the C9-C10 ethylene bridge of the [2.2]paracyclophane moiety. The chiral auxiliary is easily removed and quantitatively recovered.

MNBA-mediated β-lactone formation: Mechanistic studies and application for the asymmetric total synthesis of tetrahydrolipstatin

Various β-lactones were prepared from β-hydroxycarboxylic acids by intramolecular dehydration condensation using MNBA, an effective coupling reagent, along with a nucleophilic catalyst. The transition state that provides the desired 4-membered ring model system is disclosed by density functional theory (DFT) calculations, and the structural features of the transition form are discussed. This method was successfully applied to the asymmetric total synthesis of tetrahydrolipstatin (THL), an antiobestic drug used in clinical treatment to inhibit the activity of pancreatic lipase.

Rhenium-catalyzed reaction of carbonyl compounds with ketene silyl acetals

It was found that rhenium complex is an effective catalyst for the reaction of carbonyl compounds with ketene silyl acetals. A wide range of β-silyloxy esters is obtained by the treatment of carbonyl compounds with ketene silyl acetals in the presence of