241479-74-3 Usage
Description
(αS,βR)-β-(2,5-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanenitrile is a chemical compound with a complex structure, characterized by its triazole and phenyl rings, as well as its fluorine and nitrile functional groups. This molecule is known for its role as an intermediate in the synthesis of pharmaceutical compounds.
Uses
Used in Pharmaceutical Industry:
(αS,βR)-β-(2,5-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanenitrile is used as an intermediate in the synthesis of Isavuconazole (I777830) for the treatment of invasive fungal infections. Its unique structure contributes to the antifungal properties of the final drug product, making it a valuable component in the development of effective antifungal therapies.
In the synthesis of Isavuconazole, this compound serves as a key building block, providing the necessary structural elements for the final product. The antifungal activity of Isavuconazole is attributed to its ability to inhibit the synthesis of fungal cell membranes, thereby disrupting the growth and proliferation of invasive fungal pathogens.
Check Digit Verification of cas no
The CAS Registry Mumber 241479-74-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,4,1,4,7 and 9 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 241479-74:
(8*2)+(7*4)+(6*1)+(5*4)+(4*7)+(3*9)+(2*7)+(1*4)=143
143 % 10 = 3
So 241479-74-3 is a valid CAS Registry Number.
241479-74-3Relevant articles and documents
AN IMPROVED PROCESS FOR THE PREPARATION OF TRIAZOLE DERIVATIVES
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, (2021/12/31)
The present invention relates to an improved process for the preparation of triazole derivatives such as ravuconazole and isavuconazole.
Preparation method of isavuconazole intermediate
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Paragraph 0079-0088, (2019/12/09)
The invention provides a preparation method of an isavuconazole intermediate. Specifically, the present invention provides a method for preparing (2R,3S)-1-(1H-1,2,4-triazol-1-yl)-2-(2,5-difluorophenyl)-3-cyano-2-butanol (an intermediate 10) by carrying out a ring-opening reaction on (2R,3S)-2-(2,5-difluorophenyl)-3-methyl-2-[(1H-1,2,4-triazol-1-yl)methyl]ethylene oxide (an intermediate 9) and trimethylcyanosilane in the presence of tetrabutylammonium fluoride (TBAF). The product obtained by the method provided by the invention has high purity and yield, and the method has mild conditions, iseasy to control, and is suitable for industrial mass production.
Preparation method of isavuconazole intermediate
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, (2016/10/24)
The invention belongs to the technical field of chemical drug intermediate preparation and relates to a preparation method of an isavuconazole intermediate. The preparation method is a 4-(2-((2R, 3R)-3-(2, 5-difluorophenyl)-3-hydroxy-4-(1H-1, 2, 4-triazole-1-yl)butane-2-yl)thiazole-4-yl)benzontrile preparation method. The 4-(2-((2R, 3R)-3-(2, 5-difluorophenyl)-3-hydroxy-4-(1H-1, 2, 4-triazole-1-yl)butane-2-yl)thiazole-4-yl)benzontrile has a structural formula (I) shown in the description.
