24486-40-6

Basic information

• Product Name: O-(4-Hydroxy-3,5-di(125I)iodophenyl)-3,5-di(125I)iodo-L-tyrosine
• Synonyms: O-(4-Hydroxy-3,5-di(125I)iodophenyl)-3,5-di(125I)iodo-L-tyrosine;Thyroxine I-125
• CAS NO: 24486-40-6
• Molecular Formula: C15H11I4NO4
• Molecular Weight: 769.255
• Mol File: 24486-40-6.mol
• Article Data: 23

Chemical Properties

• Appearance: /
• CAS DataBase Reference: O-(4-Hydroxy-3,5-di(125I)iodophenyl)-3,5-di(125I)iodo-L-tyrosine(CAS DataBase Reference)
• NIST Chemistry Reference: O-(4-Hydroxy-3,5-di(125I)iodophenyl)-3,5-di(125I)iodo-L-tyrosine(24486-40-6)
• EPA Substance Registry System: O-(4-Hydroxy-3,5-di(125I)iodophenyl)-3,5-di(125I)iodo-L-tyrosine(24486-40-6)

Safety Data

• Hazardous Substances Data: 24486-40-6(Hazardous Substances Data)

Usage

Uses

Tetramet (Abbott).

Upstream product

• 534-51-0 3,5-diiodo-DL-thyronine 
• 300-39-0 3,5-diiodo-l-tyrosine 
• 1041-01-6 3,5-diiodo-L-thyronine 
• 1027-28-7 N-acetyl-3,5-diiodo-L-tyrosine 
• 27059-94-5 iodoacetamide 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 7722-84-1 dihydrogen peroxide 
• 71-36-3 butan-1-ol 
• 968-21-8 H-Leu-Tyr-OH 
• 7553-56-2 iodine 
• 96679-34-4 3.5-diiodo-N.O-diacetyl-L-tyrosine 
• 94298-44-9 N-formyl-3,5-diiodo-DL-thyronine 
• 94298-44-9 N-formyl-3,5-diiodo-L-thyronine 
• 60-18-4 L-tyrosine 

Downstream Products

• 101096-70-2 3-amino-3-[4-(4-hydroxy-phenoxy)-3,5-diiodo-phenyl]-propionic acid 
• 2389-84-6 4-(4-hydroxy-phenoxy)-3,5-diiodo-trans-cinnamic acid 
• 2278-95-7 4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-trans-cinnamic acid 
• 1396518-43-6 2-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]acetaldehyde 
• 88404-22-2 2-[(tert-butoxycarbonyl)amino]-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid 
• 1234572-94-1 triisopropylsilyl 2-(tert-butoxycarbonylamino)-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoate 
• 1234572-95-2 oxiran-2-ylmethyl 2-(tert-butoxycarbonylamino)-3-(4-(3,5-diiodo-4-(oxiran-2-ylmethoxy)phenoxy)-3,5-diiodophenyl)propanoate 
• 1234572-96-3 triisopropylsilyl 2-(tert-butoxycarbonylamino)-3-(4-(3,5-diiodo-4-(oxiran-2-ylmethoxy)phenoxy)-3,5-diiodophenyl)propanoate 

Relevant articles and documents

Liquid levothyroxine formulations

Embodiments of the present invention provide levothyroxine solutions that consist of from about 0.001% w/v to about 0.01% w/v of a levothyroxine; at least 70% w/w of a glycerol; less than 30% w/w of a water; and from about 0.01% w/w to about 1.5% w/w of an ethylenediaminetetraacetic acid (EDTA). Such levothyroxine solutions are characterized by exhibiting levothyroxine storage stability.

A PROCESS FOR PREPARATION OF LEVOTHYROXINE AND SALTS THEREOF

The present invention relates to a process for the preparation of Levothyroxine and salts thereof. The process described in the present invention provides increase in the yields and purity comprising the use of sodium iodide and sodium hypochlorite as iodinating agent.