24568-11-4

Basic information

• Product Name: AcetaMide, N-(4-broMophenyl)-2,2,2-trifluoro-
• Synonyms: AcetaMide, N-(4-broMophenyl)-2,2,2-trifluoro-
• CAS NO: 24568-11-4
• Molecular Formula: C₈H₅BrF₃NO
• Molecular Weight: 268.0306096
• Mol File: 24568-11-4.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: AcetaMide, N-(4-broMophenyl)-2,2,2-trifluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: AcetaMide, N-(4-broMophenyl)-2,2,2-trifluoro-(24568-11-4)
• EPA Substance Registry System: AcetaMide, N-(4-broMophenyl)-2,2,2-trifluoro-(24568-11-4)

Safety Data

• Hazardous Substances Data: 24568-11-4(Hazardous Substances Data)

Upstream product

• 106-40-1 4-bromo-aniline 
• 407-25-0 trifluoroacetic anhydride 
• 76-05-1 trifluoroacetic acid 
• 354-38-1 2,2,2-trifluoroacetamide 
• 589-87-7 1,4-bromoiodobenzene 
• 1310569-10-8 N-(4-bromophenyl)-2,2,2-trifluoroethanethioamide 
• 250674-72-7 C₈H₄BrClF₃N 
• 13081-18-0 ethyl-3,3,3-trifluoropyruvate 

Downstream Products

• 347-37-5 2,2,2-trifluoro-4'-phenylacetanilide 
• 106-40-1 4-bromo-aniline 
• 338452-58-7 N-(4-bromo-phenyl)-N-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2,2,2-trifluoro-acetamide 
• 1628200-43-0 2,2,2-trifluoro-N-(4-(1,1,1-trifluorobuta-2,3-dien-2-yl)phenyl)acetamide 
• 209917-42-0 4-(2,2,2-trifluroacetamide)phenylboronic acid 
• 50885-29-5 4-bromo-N-(2,2,2-trifluoroethyl)benzenamine 

Relevant articles and documents

Microwave-promoted trifluoroacetylation of amines with TiO(CF3CO2)2

Conversion of amines to their corresponding trifluoroacetamides was performed with TiO(CF3CO2)2 in a conventional microwave oven under solvent-free conditions in excellent yields.

Meta Selective C-H Borylation of Sterically Biased and Unbiased Substrates Directed by Electrostatic Interaction

An electrostatically directed meta borylation of sterically biased and unbiased substrates is described. The borylation follows an electrostatic interaction between the partially positive and negative charges between the ligand and substrate. With this strategy, it has been demonstrated that a wide number of challenging substrates, especially 4-substituted substrates, can selectively be borylated at the meta position. Moreover, unsubstituted substrates also displayed excellent meta selectivity. The reaction employs a bench-stable ligand and proceeds at a milder temperature, precluding the need to synthesize a bulky and sophisticated ligand/template.

Overcoming inaccessibility of fluorinated imines-synthesis of functionalized amines from readily available fluoroacetamides

Although imines are convenient substrates for the synthesis of functionalized amines, they may be hard to obtain, as in the case of fluorinated imines. To aid in overcoming this issue, we propose a protocol of corresponding amine synthesis from simple fluoroacetic acid-derived amides using Schwartz's reagent.

Catalytic reduction of amides to amines by electrophilic phosphonium cations via FLP hydrosilylation

A catalytic methodology for the conversion of amides to amines is reported. Of the 25 examples described, 14 examples involve the reduction of N-trifluoroacetamides to the corresponding trifluoroethylamines. These reductions are achieved by catalytic hydrosilylation of the amide mediated by an electrophilic phosphonium cation (EPC) catalyst.