24751-68-6

Basic information

• Product Name: O^2'_,O3'_,O5'-tribenzoyl-5-bromomethyl-uridine
• CAS NO: 24751-68-6
• Molecular Weight: 649.451
• Mol File: 24751-68-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: O^2'_,O3'_,O5'-tribenzoyl-5-bromomethyl-uridine(CAS DataBase Reference)
• NIST Chemistry Reference: O^2'_,O3'_,O5'-tribenzoyl-5-bromomethyl-uridine(24751-68-6)
• EPA Substance Registry System: O^2'_,O3'_,O5'-tribenzoyl-5-bromomethyl-uridine(24751-68-6)

Safety Data

• Hazardous Substances Data: 24751-68-6(Hazardous Substances Data)

Upstream product

• 3180-76-5 2',3',5'-tri-O-benzoyluridine 

Downstream Products

• 30414-00-7 5-(hydroxymethyl)uridine 

Relevant articles and documents

Interstrand cross-link and bioconjugate formation in RNA from a modified nucleotide

RNA oligonucleotides containing a phenyl selenide derivative of 5-methyluridine were chemically synthesized by solid-phase synthesis. The phenyl selenide is rapidly converted to an electrophilic, allylic phenyl seleneate under mild oxidative conditions. The phenyl seleneate yields interstrand cross-links when part of a duplex and is useful for synthesizing oligonucleotide conjugates. Formation of the latter is illustrated by reaction of an oligonucleotide containing the phenyl selenide with amino acids in the presence of mild oxidant. The products formed are analogous to those observed in tRNA that are believed to be formed posttranslationally via a biosynthetic intermediate that is chemically homologous to the phenyl seleneate. (Chemical Equation Presented).