30414-00-7

Basic information

• Product Name: 5-(Hydroxymethyl)uridine
• Synonyms: 5-(Hydroxymethyl)uridine;5-Hydroxymethyl-Ur
• CAS NO: 30414-00-7
• Molecular Formula: C₁₀H₁₄N₂O₇
• Molecular Weight: 274.2274
• Mol File: 30414-00-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 167-168 °C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.689g/cm³
• Refractive Index: 1.646
• PKA: 9.01±0.10(Predicted)
• CAS DataBase Reference: 5-(Hydroxymethyl)uridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(Hydroxymethyl)uridine(30414-00-7)
• EPA Substance Registry System: 5-(Hydroxymethyl)uridine(30414-00-7)

Safety Data

• Hazardous Substances Data: 30414-00-7(Hazardous Substances Data)

Usage

General Description

5-(Hydroxymethyl)uridine is a chemical compound that belongs to the class of modified nucleosides. It is a naturally occurring derivative of uridine, which is found in various tissues and fluids of the human body. 5-(Hydroxymethyl)uridine plays a crucial role in RNA modification and is also involved in the biosynthesis of certain types of RNA. 5-(Hydroxymethyl)uridine has been studied for its potential therapeutic applications, particularly in the treatment of mitochondrial disorders and as a potential neuroprotective agent. Additionally, 5-(Hydroxymethyl)uridine has been investigated for its effects on mitochondrial biogenesis and its potential role in improving energy metabolism in cells. Overall, this compound has garnered interest for its potential biological and therapeutic significance.

InChI:InChI=1/C10H14N2O7/c13-2-4-1-12(10(18)11-8(4)17)9-7(16)6(15)5(3-14)19-9/h1,5-7,9,13-16H,2-3H2,(H,11,17,18)/t5-,6-,7-,9-/m1/s1

Upstream product

• 50-00-0 formaldehyd 
• 58-96-8 uridine 
• 3816-77-1 2',3'-O-isopropylidene-5-hydroxymethyl-uridine 
• 362-43-6 2',3'-O-isopropylideneuridine 
• 3180-76-5 2',3',5'-tri-O-benzoyluridine 
• 24751-68-6 O^2'_,O3'_,O5'-tribenzoyl-5-bromomethyl-uridine 

Downstream Products

• 1463-10-1 5-Methyluridine 
• 917482-58-7 5-t-butyldiphenylsilyloxymethyl-5'-O-t-butyldiphenylsilyluridine 
• 917482-60-1 5-t-butyldiphenylsilyloxymethyl-5'-O-t-butyldiphenylsilyl-2',3'-didehydro-2',3'-dideoxyuridine 
• 917482-59-8 5-t-butyldiphenylsilyloxymethyl-5'-O-t-butyldiphenylsilyluridine 2',3'-bisxanthate 
• 158532-72-0 2',3'-didehydro-2',3'-dideoxy-5-hydroxymethyluridine 
• 220895-39-6 acetic acid 3-acetoxy-2-acetoxymethyl-6-(1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-ylmethoxy)-5-(2,2,2-trifluoro-acetylamino)-tetrahydro-pyran-4-yl ester 

Relevant articles and documents

SYNTHESIS AND STRUCTURE OF HIGH POTENCY RNA THERAPEUTICS

This invention provides expressible polynucleotides, which can express a target protein or polypeptide. Synthetic mRNA constructs for producing a protein or polypeptide can contain one or more 5′ UTRs, where a 5′ UTR may be expressed by a gene of a plant. In some embodiments, a 5′ UTR may be expressed by a gene of a member of Arabidopsis genus. The synthetic mRNA constructs can be used as pharmaceutical agents for expressing a target protein or polypeptide in vivo.

Alternative synthetic routes to 2′,3′-didehydro-2′,3′-dideoxy-5-hydroxymethyluridine

Alternative syntheses for the nucleoside analogue 2′,3′-didehydro-2′,3′-dideoxy-5-hydroxymethyluridine starting from 5-methyluridine and uridine are described.

Synthesis of 5-(2-amino-2-deoxy-β-D-glucopyranosyloxymethyl)-2'- deoxyuridine and its incorporation into oligothymidylates

The protected 5-(2-amino-2-deoxy-β-D-glucopyranosyloxymethyl)-2'- deoxyuridine phosphoramidite 15 has been prepared from uridine in 12 steps. When incorporated into oligodeoxyribonucleotides the novel nucleoside analog 5 leads to decreased binding affinit