24897-51-6 Usage
Description
URACIL-6-D1, also known as 6-deuterium-uracil, is a stable isotope-labeled compound derived from the pyrimidine base uracil. It is characterized by the replacement of one hydrogen atom with a deuterium atom, which is a non-radioactive isotope of hydrogen. This modification provides unique properties for various applications in the field of medicine and pharmaceuticals.
Uses
Used in Pharmaceutical Industry:
URACIL-6-D1 is used as a building block for the preparation of stabilized nucleotides, which are essential for the medical treatment of various viral infections and cancer. Its stable isotope labeling enhances the stability and efficacy of the resulting nucleotides.
Used in Antiviral Applications:
URACIL-6-D1 is used as a key component in the development of antiviral drugs for the treatment of Hepatitis C, Respiratory Syncytial Virus (RSV), and Herpes Simplex Virus (HSV). The incorporation of URACIL-6-D1 into the nucleotide structure of these drugs improves their effectiveness in inhibiting viral replication and reducing the severity of the diseases.
Used in Anticancer Applications:
URACIL-6-D1 is also utilized as an antitumor agent, where it is used in the synthesis of nucleotide-based drugs that target cancer cells. The stable isotope labeling of URACIL-6-D1 contributes to the enhanced selectivity and potency of these drugs, making them more effective in combating cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 24897-51-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,8,9 and 7 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 24897-51:
(7*2)+(6*4)+(5*8)+(4*9)+(3*7)+(2*5)+(1*1)=146
146 % 10 = 6
So 24897-51-6 is a valid CAS Registry Number.
24897-51-6Relevant articles and documents
Mechanistic studies of antibody-catalyzed pyrimidine dimer photocleavage
Jacobsen, John R.,Cochran, Andrea G.,Stephans, James C.,King, David S.,Schultz, Peter G.
, p. 5453 - 5461 (1995)
An antibody elicited against the trans, syn uracil cyclobutane dimer hapten 1 catalyzes the light-dependent cleavage of uracil dimers 1 and 2 to the corresponding monomers 3 and 4. Kinetic analysis of the antibody-catalyzed reaction affords a value of k(cat)/K(M) = 1.7 x 103 M-1 min-1 for substrate 2, and comparison to the uncatalyzed reaction gives a rate acceleration of k(cat)/k(uncat) = 380. The wavelength dependence of the reaction and fluorescence quenching behavior suggest that a tryptophan residue is acting as a photosensitizer. The reaction mechanism was probed by measurement of secondary deuterium isotope effects. Substrates with selective deuterium substitutions in the cyclobutane ring were prepared, and isotope effects were measured by the method of interual competition using electrospray-ionization mass spectrometry to quantify the products. Kinetic isotope effects of (α-D)(V/K) = 1.11, 1.14, and 1.20 were observed for the 5,5'-, 6,6'-, and 5,5',6,6'-labeled substrates, respectively. These results are comparable to those observed in a similar study on the E. coli enzyme DNA photolyase and suggest that the reaction may proceed via a radical anion intermediate with concerted breakage of the 5,5' and 6,6' bonds. Alternatively the reaction may proceed via a mechanism in which the first bond is cleaved in a reversible fashion.
