24897-55-0 Usage
Description
URACIL-D4, also known as Deuterated Uracil, is a labeled compound form of Uracil (U801000) which is a nitrogenous base found in RNA nucleosides. It is characterized by the presence of deuterium atoms, which are isotopes of hydrogen, in its molecular structure. This deuteration can provide unique properties and applications for URACIL-D4 compared to its non-deuterated counterpart.
Uses
Used in Chemical and Pharmaceutical Research:
URACIL-D4 is used as a labeled compound for various research applications in the fields of chemistry and pharmaceuticals. The incorporation of deuterium atoms in URACIL-D4 can enhance the stability and solubility of the molecule, making it a valuable tool for studying the structure, function, and interactions of RNA nucleosides and their derivatives.
Used in Mass Spectrometry:
In mass spectrometry, URACIL-D4 can be used as an internal standard or a reference compound to improve the accuracy and precision of mass measurements. The presence of deuterium atoms in URACIL-D4 allows for better differentiation between isotopologues and can help in the identification and quantification of similar compounds.
Used in NMR Spectroscopy:
URACIL-D4 can be employed as a labeled reference compound in nuclear magnetic resonance (NMR) spectroscopy. The deuterium atoms in URACIL-D4 can provide distinct NMR signals, which can be used to study the chemical environment and interactions of RNA nucleosides and their derivatives.
Used in Biochemical and Molecular Biology Studies:
URACIL-D4 can be utilized as a stable isotope-labeled compound in biochemical and molecular biology research. It can be used to investigate the mechanisms of RNA synthesis, degradation, and interactions with other biomolecules, as well as to study the effects of deuteration on the biological activity of RNA nucleosides.
Used in Drug Development:
In the pharmaceutical industry, URACIL-D4 can be used as a starting material or a building block for the synthesis of novel RNA-targeting drugs. The deuterium-labeled nature of URACIL-D4 can potentially improve the pharmacokinetic and pharmacodynamic properties of the resulting drug candidates, making them more effective and stable in biological systems.
Check Digit Verification of cas no
The CAS Registry Mumber 24897-55-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,8,9 and 7 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 24897-55:
(7*2)+(6*4)+(5*8)+(4*9)+(3*7)+(2*5)+(1*5)=150
150 % 10 = 0
So 24897-55-0 is a valid CAS Registry Number.
24897-55-0Relevant articles and documents
Nucleic acid bases studed by matrix isolation vibrational spectroscopy: uracil and deuterated uracils
Barnes, A. J.,Stuckey, M. A.,Gall, L. Le
, p. 419 - 432 (2007/10/02)
A vibrational assignment of the isolated uracil molecule is presented, based on i.r. and Raman spectra of uracil trapped in argon and nitrogen matrices and i.r. spectra of seven deuterated derivatives of uracil isolated in argon matrices.The observed spectra agree well with previous quantumm mechanical calculations.The relationships observed between the monomer bands, bands due to associated uracil in argon matrices and the spectrum of the pure solid lead to a revised vibrational assignment for uracil in the solid phase.As well as large shifts in the NH stretching and out-of-plane bending modes between the monomer and the hydrogen-bonded solid, many other bands show appreciable shifts as a consequence of the extensive mixing of the NH in-plane bending modes with the CH in-plane bending and ring stretching modes.The spectrum of the associated uracil species in matrices suggests that it is a cyclic dimer linked by C2=O...H-N1 hydrogen bonds.
