24955-54-2

Basic information

• Product Name: L-Leucine, N-[N-[(phenylmethoxy)carbonyl]glycyl]-, hydrazide
• CAS NO: 24955-54-2
• Molecular Formula: C16H24N4O4
• Molecular Weight: 336.391
• Mol File: 24955-54-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: L-Leucine, N-[N-[(phenylmethoxy)carbonyl]glycyl]-, hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: L-Leucine, N-[N-[(phenylmethoxy)carbonyl]glycyl]-, hydrazide(24955-54-2)
• EPA Substance Registry System: L-Leucine, N-[N-[(phenylmethoxy)carbonyl]glycyl]-, hydrazide(24955-54-2)

Safety Data

• Hazardous Substances Data: 24955-54-2(Hazardous Substances Data)

Upstream product

• 50622-95-2 benzyl (2-azido-2-oxoethyl)carbamate 
• 1421-69-8 (S)-2-(2-Benzyloxycarbonylamino-acetylamino)-4-methyl-pentanoic acid 
• 2666-93-5 (S)-Leu-OMe 
• 83435-46-5 ((S)-4-isobutyl-5-oxo-4,5-dihydro-oxazol-2-ylmethyl)-carbamic acid benzyl ester 
• 7352-21-8 Cbz-glycylleucine ethyl ester 
• 17331-93-0 N-benzyloxycarbonylglycyl-L-leucine methyl ester 
• 87023-85-6 1-(Cbz-glycyl)-3,5-dimethylpyrazole 
• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 1145-81-9 ethyl 2-(benzyloxycarbonylamino)ethanoate 
• 5680-83-1 N-(benzyloxycarbonyl)glycine hydrazide 

Downstream Products

• 118908-89-7 3-carboxypropionylglycyl-leucyl-S-benzylcysteine p-nitroanilide 
• 118908-85-3 ({(S)-1-[(R)-2-Benzylsulfanyl-1-(4-nitro-phenylcarbamoyl)-ethylcarbamoyl]-3-methyl-butylcarbamoyl}-methyl)-carbamic acid benzyl ester 

Relevant articles and documents

New system for peptide synthesis using N-acylpyrazoles

New system of peptide synthesis was described. The extension of one amino acid unit on the peptide chain was constituted from only 2 reaction steps, the conversion from esters to the corresponding N-acylpyrazoles and the subsequent aminolysis with amino esters. This new system was distinctive from the conventional peptide synthesis, which was consisted of 3 steps of the deprotection, the activation and the condensation. Moreover, the key intermediate N-acylpyrazoles exhibited the excellent properties of high sensitivity and separability for the chiral column on HPLC using the UV detector.