2497-02-1Relevant articles and documents
Synthesis and catalytic activity of histidine-based NHC ruthenium complexes
Monney, Angele,Venkatachalam, Galmari,Albrecht, Martin
, p. 2716 - 2719 (2011)
Main-chain C,N-protected histidine has been successfully alkylated at both side-chain nitrogens. The corresponding histidinium salt was metallated with ruthenium(ii) by a transmetalation procedure, thus providing histidine-derived NHC ruthenium complexes. These bio-inspired complexes show appreciable activity in the catalytic transfer hydrogenation of ketones. The Royal Society of Chemistry 2011.
The study of the effect of histidine derivatives as a novel antinociceptive and anti-inflammatory activity
Ramadhan, Usama H.,Al-Salihi, Niran J.
, p. 1832 - 1842 (2011)
This study explains the biochemical activity of histidine derivatives The compounds were identified by CHN analysis, FT-IR and H1 NMR. The results certified that the chemical structures of the prepared compounds. The anti-inflammatory and antinociceptive activity was studied by two different tests; the hot plate test and writhing test for analgesic activity and two tests for anti-inflammatory activity they are formalin induced inflammation test and carrageen an induced inflammation test. The histidine derivatives were found to have potent activity as anti-inflammatory and antinociceptive. The active compounds were tested to acute toxicity. It was found that they are safety to the dose 5 g/kg orally in mice without any mortality. Copyright E-Journal of Chemistry 2004-2011.
Emergence of a Promiscuous Peroxidase Under Non-Equilibrium Conditions**
Bal, Subhajit,Das, Dibyendu,Pal, Sumit,Reja, Antara,Tikader, Baishakhi
supporting information, (2021/12/06)
Herein, we report the substrate induced generation of a transient catalytic microenvironment from a single amino acid functionalized fatty acid in presence of a cofactor hemin. The catalytic state accessed under non-equilibrium conditions showed acceleration of peroxidase activity resulting in degradation of the substrate and subsequently led to disassembly. Equilibrated systems could not access the three-dimensional microphases and showed substantially lower catalytic activity. Further, the assembled state showed latent catalytic function (promiscuity) to hydrolyze a precursor to yield the same substrate. Consequently, the assembly demonstrated protometabolism by exploiting the peroxidase-hydrolase cascade to augment the lifetime and the mechanical properties of the catalytic state.
Effects of Imidazole and Its Derivatives on Radiation-Induced Dephosphorylation of Glycero-1-Phosphate in Deaerated Aqueous Solutions
Brinkevich,Maliborskii, A. Ya.,Melnichuk,Sverdlov,Grigor’ev, Yu. V.,Shadyro
, p. 155 - 164 (2021/04/22)
Abstract: The effect of imidazole, histamine, histidine, and their nitro derivatives on the radiation-induced transformations of glycero-1-phosphate and ethanol in deaerated aqueous solutions at pH 7 has been studied It has been found that the test substances in equimolar concentrations to glycero-1-phosphate inhibit the radiation-induced dephosphorylation by scavenging the radical products of water radiolysis. At an additive-to-substrate ratio of 1 : 100, the nitro derivatives of histidine and metronidazole efficiently inhibit the radiation-induced dephosphorylation of glycero-1-phosphate due to the interaction with its carbon-centered radicals with constants of (3.1–5.1) × 109 L mol–1 s–1. Using the radiolysis of a 1 M aqueous solution of ethanol, it was demonstrated that 5-nitroimidazoles quantitatively oxidize α-hydroxyethyl radicals; this manifested itself in the absence of 2,3-butanediol among the radiolysis products and a ~20-fold increase in the yield of acetaldehyde, as compared to that in a control experiment. Thus, metronidazole and the nitro derivatives of histidine are capable of suppressing the radiation-induced dephosphorylation of glycero-1-phosphate and, probably, glycerophospholipids due to the oxidation of their α-hydroxylcontaining carbon-centered radicals.