25021-48-1

Basic information

• Product Name: 4-(2-PHENYL-1,3-THIAZOL-4-YL)ANILINE
• Synonyms: IFLAB-BB F1912-0013;4-(2-PHENYL-1,3-THIAZOL-4-YL)ANILINE;4-(2-Phenyl-thiazol-4-yl)-phenylamine
• CAS NO: 25021-48-1
• Molecular Formula: C₁₅H₁₂N₂S
• Molecular Weight: 252.33
• Mol File: 25021-48-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 280-290 °C
• Boiling Point: 455.3±37.0 °C(Predicted)
• Appearance: /
• Density: 1.230±0.06 g/cm3(Predicted)
• PKA: 3.17±0.10(Predicted)
• CAS DataBase Reference: 4-(2-PHENYL-1,3-THIAZOL-4-YL)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-PHENYL-1,3-THIAZOL-4-YL)ANILINE(25021-48-1)
• EPA Substance Registry System: 4-(2-PHENYL-1,3-THIAZOL-4-YL)ANILINE(25021-48-1)

Safety Data

• Hazardous Substances Data: 25021-48-1(Hazardous Substances Data)

Upstream product

• 2521-25-7 4-(4-nitrophenyl)-2-phenylthiazole 
• 140-49-8 N-[4-(chloroacetyl)phenyl]acetamide 
• 2227-79-4 benzenecarbothioamide 
• 2631-71-2 4-aminophenacyl chloride 
• 1826-14-8 2,4-diphenylthiazole 
• 75129-17-8 C₁₇H₁₄N₂OS 
• 99-81-0 4-Nitrophenacyl bromide 
• 21675-02-5 4-acetylaminophenacyl bromide 
• 2719-21-3 4-(N-acetylamino)acetophenone 
• 99-92-3 p-aminobenzophenone 

Downstream Products

• 25020-71-7 1,3-bis-[4-(2-phenyl-thiazol-4-yl)-phenyl]-thiourea 
• 68173-81-9 [4-(2-phenyl-thiazol-4-yl)-phenyl]-thiourea 
• 75129-34-9 4-(p-acetamidobenzenesulphanilamido)-2-phenylthiazole 
• 65321-86-0 4-(4-azido-phenyl)-2-phenyl-thiazole 
• 65321-99-5 1-[4-(2-phenyl-thiazol-4-yl)-phenyl]-5-p-tolyl-1H-[1,2,3]triazole 
• 65321-89-3 4-(2-phenyl-thiazol-4-yl)-N-(triphenyl-λ⁵-phosphanylidene)-aniline 
• 75129-27-0 6-(2-phenyl-thiazol-4-yl)-benzothiazol-2-ylamine 
• 75129-35-0 2-phenyl-4-(p-aminophenylthiazolyl)sulphonamide 
• 75129-50-9 4-acetylamino-N-[6-(2-phenyl-thiazol-4-yl)-benzothiazol-2-yl]-benzenesulfonamide 
• 75129-51-0 4-amino-N-[6-(2-phenyl-thiazol-4-yl)-benzothiazol-2-yl]-benzenesulfonamide 
• 68173-65-9 4-(2-phenyl-thiazol-4-yl)-N-(4-phenyl-thiazol-2-yl)-aniline 
• 68173-68-2 4-(2-phenyl-thiazol-4-yl)-N-(4-p-tolyl-thiazol-2-yl)-aniline 
• 68173-66-0 N-[4-(4-chloro-phenyl)-thiazol-2-yl]-4-(2-phenyl-thiazol-4-yl)-aniline 
• 68173-67-1 N-(4-(p-Bromphenyl)-2-thiazolyl)-p-(2-phenyl-4-thiazolyl)anilin 

Relevant articles and documents

Synthesis and antiproliferative activity evaluation of new thiazole-benzimidazole derivatives using real-time cell analysis (RTCA DP)

A series of new 2-[(5-substituted-1H-benzimidazol-2-yl)thio]-N-[4-[2-phenylthiazol-4-yl]phenyl]acetamide derivatives (4a-p) were synthesized according to the reported literature, and anticancer activity of the compounds was evaluated. Cytotoxic activity w

Discovery of amide replacements that improve activity and metabolic stability of a bis-amide smoothened antagonist hit

A bis-amide antagonist of Smoothened, a seven-transmembrane receptor in the Hedgehog signaling pathway, was discovered via high throughput screening. In vitro and in vivo experiments demonstrated that the bis-amide was susceptible to N-acyl transferase mediated amide scission. Several bioisosteric replacements of the labile amide that maintained in vitro potency were identified and shown to be metabolically stable in vitro and in vivo.

Benzene compounds

The present invention provides novel benzene compounds presented by the following formulas, and analogs thereof, that exert an ACC activity-inhibiting effect that is effective in the treatment of obesity, hyperlipemia, fatty liver, hyperglycemia, impaired glucose tolerance, diabetes, diabetic complications (diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, and diabetic macroangiopathy, hypertension, arteriosclerosis), hypertension, and arteriosclerosis.