25050-22-0

Basic information

• Product Name: Benzamide, N-(3,5-dimethylphenyl)-
• CAS NO: 25050-22-0
• Molecular Formula: C15H15NO
• Molecular Weight: 225.29
• Mol File: 25050-22-0.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: Benzamide, N-(3,5-dimethylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-(3,5-dimethylphenyl)-(25050-22-0)
• EPA Substance Registry System: Benzamide, N-(3,5-dimethylphenyl)-(25050-22-0)

Safety Data

• Hazardous Substances Data: 25050-22-0(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 108-69-0 3,5-dimethylaminoaniline 
• 3262-89-3 triphenylboroxine 
• 203321-89-5 (3,5-dimethylphenyl)carbamic acid 1,1-dimethylethyl ester 
• 4406-77-3 2-Phenyl-1,3,2-dioxaborinane 
• 5123-13-7 5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane 
• 201230-82-2 carbon monoxide 
• 2996-92-1 phenyl trimethylsiloxane 
• 19226-36-9 3-phenyl-5H-1,4,2-dioxazol-5-one 
• 172975-69-8 3,5-dimethylphenyl boronic acid 
• 100-58-3 phenylmagnesium bromide 
• 54132-75-1 3,5-dimethylphenyl isocyanate 
• 99802-96-7 2-benzoyl-1,3-dimethyl-1H-imidazol-3-ium iodide 
• 30148-17-5 (1-methyl-1H-imidazol-2-yl)(phenyl)methanone 

Downstream Products

• 51625-18-4 N-Allyl-N-benzoyl-3,5-dimethyl-anilin 
• 124043-95-4 N-benzyl-3,5-dimethylaniline 
• 502161-89-9 3-[benzyl-(3,5-dimethylphenyl)-amino]-cyclopent-2-enone 
• 502161-87-7 3-[benzyl-(3,5-dimethylphenyl)-amino]-cyclohex-2-enone 
• 65001-45-8 N-allyl-3,5-dimethylbenzenamine 
• 65001-46-9 2-allyl-3,5-dimethylaniline 
• 65001-48-1 (Z)-3,5-Dimethyl-2-(1'-propenyl)-anilin 
• 65001-49-2 (E)-3,5-Dimethyl-2-(1'-propenyl)-anilin 

Relevant articles and documents

Visible-Light-Promoted Iron-Catalyzed N-Arylation of Dioxazolones with Arylboronic Acids

A visible-light-promoted and simple iron salt-catalyzed N-arylation was achieved efficiently under external photosensitizer-free conditions. Arylboronic acids and bench-stable dioxazolones were used for this cross-coupling reaction. This reaction features high reactivity, wide substrate scope, good functional group tolerance, simple operation procedure, and mild reaction conditions. Preliminary mechanistic investigations were conducted to support a radical pathway. This method may contribute to shift the paradigm of iron-catalyzed C-N bond construction and nitrene transfer chemistry.

Practical one-pot amidation of N -Alloc-, N -Boc-, and N -Cbz protected amines under mild conditions

A facile one-pot synthesis of amides from N-Alloc-, N-Boc-, and N-Cbz-protected amines has been described. The reactions involve the use of isocyanate intermediates, which are generated in situ in the presence of 2-chloropyridine and trifluoromethanesulfonyl anhydride, to react with Grignard reagents to produce the corresponding amides. Using this reaction protocol, a variety of N-Alloc-, N-Boc-, and N-Cbz-protected aliphatic amines and aryl amines were efficiently converted to amides with high yields. This method is highly effective for the synthesis of amides and offers a promising approach for facile amidation.

Base-Promoted Amidation and Esterification of Imidazolium Salts via Acyl C-C bond Cleavage: Access to Aromatic Amides and Esters

Imidazolium salts have been effectively employed as suitable acyl transfer agents in amidation and esterification in organic synthesis. The weak acyl C(O)-C imidazolium bond was exploited to generate acyl electrophiles, which further react with amines and alcohols to afford amides and esters. The broad substrate scope of anilines and benzylic amines and base-promoted conditions are the benefits of this route. Interestingly, phenol, benzylic alcohols, and a biologically active alcohol can also be subjected to esterification under the optimized conditions.