25109-98-2Relevant articles and documents
Selective Approaches to α- and β-Arylated Vinyl Ethers
Bolm, Carsten,Domzalska-Pieczykolan, Anna,Funes-Ardoiz, Ignacio,Furman, Bart?omiej
supporting information, (2021/11/30)
We developed simple and efficient protocols for palladium-catalyzed regioselective α- and β-arylations of structurally diverse vinyl ethers. Both catalytic methods proceed under relatively mild reactions conditions applying to a broad substrate range including more complex compounds providing arylated glucal or isochromene. Lacking the common requirement of a large reagent excess, the transformations are highly economic and limiting the waste production. Results from computational studies (DFT) provided insight into the key factors determining the pronounced regioselectivities of the investigated reactions.
Dynamic kinetic asymmetric [3 + 2] annulation reactions of aminocyclopropanes
De Nanteuil, Florian,Serrano, Eloisa,Perrotta, Daniele,Waser, Jerome
supporting information, p. 6239 - 6242 (2014/05/20)
We report the first example of a dynamic kinetic asymmetric [3 + 2] annulation reaction of aminocyclopropanes with both enol ethers and aldehydes. Using a Cu catalyst and a commercially available bisoxazoline ligand, cyclopentyl- and tetrahydrofurylamines were obtained in 69-99% yield and up to a 98:2 enantiomeric ratio using the same reaction conditions. The method gives access to important enantio-enriched nitrogen building blocks for the synthesis of bioactive compounds.
A facile solid-phase synthesis of vinyl ethers using a selenium traceless linker
Liu, Xiao-Ling,Sheng, Shou-Ri,Wang, Qiu-Ying,Sun, Wu-Kang,Xin, Qin,Ao, Hong-Yu
, p. 118 - 120 (2007/10/03)
A simple, efficient and environmentally friendly procedure for the solid-phase synthesis of vinyl ethers in good yields and purities by reaction of polystyrene-supported 2-hydroxyalkyl selenide with primary or secondary organic halides and subsequent oxid
