935-04-6Relevant articles and documents
Direct Synthesis of Deuterium-Labeled O -, S -, N-Vinyl Derivatives from Calcium Carbide
Ananikov, Valentine P.,Egorova, Ksenia S.,Ledovskaya, Maria S.,Posvyatenko, Alexandra V.,Rodygin, Konstantin S.,Voronin, Vladimir V.
, p. 3001 - 3013 (2019)
A novel methodology for the preparation of trideuterovinyl derivatives of high purity directly from alcohols, thiols, and NH-compounds was developed. Commercially available calcium carbide and D 2 O acted as a D 2 -acetylene source, and DMSO- d 6 was used to complete the formation of the D 2 C=C(D)-X fragment (X = O, S, N). Polymerization of a selected trideuterovinylated compound showed a very promising potential of these substances in the synthesis of labeled polymeric materials. Biological activity of the synthesized trideuterovinyl derivatives was evaluated and the results indicated a significant increase of cytotoxicity upon deuteration.
Preparation method of bilastine intermediate
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Paragraph 0082-0083, (2020/02/10)
The invention relates to a preparation method of a bilastine intermediate represented by a formula 1. The preparation method specifically comprises: carrying out a reaction in a first solvent in the presence of DBU by using 2-bromoethyl anisole (formula I
Calcium Carbide Looping System for Acetaldehyde Manufacturing from Virtually any Carbon Source
Rodygin, Konstantin S.,Lotsman, Kristina A.,Ananikov, Valentine P.
, p. 3679 - 3685 (2020/06/17)
A vinylation/devinylation looping system for acetaldehyde manufacturing was evaluated. Vinylation of iso-butanol with calcium carbide under solvent-free conditions was combined with hydrolysis of the resulting iso-butyl vinyl ether under slightly acidic conditions. Acetaldehyde produced by hydrolysis was collected from the reaction mixture by simple distillation, and the remaining alcohol was redirected to the vinylation step. All the inorganic co-reagents can be looped as well, and the full sequence is totally sustainable. A complete acetaldehyde manufacturing cycle was proposed on the basis of the developed procedure. The cycle was fed with calcium carbide and produced the aldehyde as a single product in a total preparative yield of 97 %. No solvents, hydrocarbons, or metal catalysts were needed to maintain the cycle. As calcium carbide in principle can be synthesized from virtually any source of carbon, the developed technology represents an excellent example of biomass and waste conversion into a valuable industrial product.