2518-13-0

Basic information

• Product Name: 2-(4-nitrophenyl)-4,5-dihydro-1,3-thiazole
• Synonyms: 2-(4-Nitrophenyl)-4,5-dihydro-1,3-thiazole; thiazole, 4,5-dihydro-2-(4-nitrophenyl)-
• CAS NO: 2518-13-0
• Molecular Formula: C₉H₈N₂O₂S
• Molecular Weight: 208.237
• Mol File: 2518-13-0.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 373.2°C at 760 mmHg
• Flash Point: 179.5°C
• Density: 1.43g/cm³
• Vapor Pressure: 1.95E-05mmHg at 25°C
• Refractive Index: 1.69
• CAS DataBase Reference: 2-(4-nitrophenyl)-4,5-dihydro-1,3-thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-nitrophenyl)-4,5-dihydro-1,3-thiazole(2518-13-0)
• EPA Substance Registry System: 2-(4-nitrophenyl)-4,5-dihydro-1,3-thiazole(2518-13-0)

Safety Data

• Hazardous Substances Data: 2518-13-0(Hazardous Substances Data)

Usage

Chemical class

thiazole

Physical form

yellow crystalline solid

Use in pharmaceutical industry

building block for drug synthesis

Potential biological activities

antimicrobial, antifungal, anticancer

Enzyme inhibition

promising for drug development and therapeutic applications

Upstream product

• 108481-60-3 4-nitro-benzoic acid-(2-bromo-ethylamide) 
• 52708-02-8 4-nitrobenzimidic acid methyl ester 
• 156-57-0 2-mercaptoethylamine hydrochloride 
• 4231-71-4 1H-1,2,3-benzotriazol-1-yl-4-nitrophenylmethanone 
• 62-23-7 4-nitro-benzoic acid 
• 619-72-7 4-nitrobenzonitrile 
• 60-23-1 Cysteamine 
• 2576-47-8 2-bromoethylamine hydrobromide 
• 26060-30-0 4-nitrothiobenzamide 
• 1129-37-9 4-nitrobenzaldehyde oxime 
• 6640-65-9 N-(2-hydroxyethyl)-4-nitrobenzamide 
• 122-04-3 4-nitro-benzoyl chloride 

Downstream Products

• 774238-35-6 4-(4,5-dihydrothiazol-2-yl)aniline 
• 54151-09-6 5-(4-nitro-phenyl)-6-(toluene-4-sulfonyloxy)-4-thia-1-aza-bicyclo[3.2.0]heptan-7-one 
• 3704-41-4 2-(4-nitrophenyl)thiazole 

Relevant articles and documents

Microwave-Assisted Synthesis of 2-Substituted 2-Thiazolines and 5,6-Dihydro-4 H -1,3-thiazines

An efficient and general method for the synthesis of 2-substituted thiazolines and 5,6-dihydro-4 H -1,3-thiazines is developed via microwave-assisted ring closure of ω-thioamidoalcohols promoted by ethyl polyphosphate (PPE). The cyclization reaction involves an S N 2-type mechanism and features the advantages of very short reaction times, high yields and a predictable stereochemical outcome. The acyclic precursors are prepared in high overall yields by an improved diacylation-thionation-saponification sequence from commercially available ω-amino alcohols. The whole process is metal-free and operationally simple.

A single-reagent-driven multistep one-pot preparation of thiazolines and 1,3-thiazines from aldoximes, nitriles, and carboxylic acids

N-(ω-Bromoalkyl)dichlorothiophosphoramidates have been designed as a new class of reagent for the single-reagent-driven multistep preparation of 2-substituted thiazolines and 1,3-thiazines from ald-oximes, nitriles, or carboxylic acids. A wide range of substrates both aromatic as well as aliphatic were investigated and found suitable for the developed protocol.

Solvent-free tandem synthesis of 2-thiazolines and 2-oxazolines catalyzed by a copper catalyst

Tandem reactions of nitriles with 2-aminoethanethiol hydrochloride or amino alcohols in the presence of a catalytic amount of cupric methacrylate (Cu II2L4, L = methacrylate) were employed to prepare 2-thiazolines and 2-ox