2576-47-8 Usage
Description
2-Bromoethylamine hydrobromide, also known as BEA-HBr, is a slight yellow to white crystalline powder that is hygroscopic and moisture sensitive. It is soluble in water and methanol but insoluble in ether, and it is incompatible with strong oxidizing agents. 2-Bromoethylamine hydrobromide is commonly found in a crystalline form and is used as a building block in various applications.
Uses
Used in Proteomics Research:
2-Bromoethylamine hydrobromide is used as a building block to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone, which are essential for proteomics research. It aids in the study and analysis of proteins, their structures, and functions.
Used in Organic and Pharmaceutical Industries:
2-Bromoethylamine hydrobromide serves as an organic and pharmaceutical intermediate, playing a crucial role in the preparation of first-aid medicines. It is a key component in the synthesis of various pharmaceutical compounds.
Used in the Synthesis of Amino-functionalized Ionic Liquid:
BEA-HBr is used as a reactant in the preparation of amino-functionalized ionic liquid, 1-aminoethyl-3-methylimidazolium hexafluorophosphate ([2-aemim][PF6]). This ionic liquid is employed as a catalyst in the synthesis of 4H-pyrans derivatives through the Knoevenagel condensation reaction involving aromatic aldehydes, malononitrile, and ethyl acetoacetate.
Used in the Synthesis of 2-(N-aryl-N-aroyl)amino-4,5-dihydrothiazole Derivatives:
2-Bromoethylamine hydrobromide is also utilized in the cyclocondensation reaction to synthesize 2-(N-aryl-N-aroyl)amino-4,5-dihydrothiazole derivatives, which have potential applications in various fields.
Used in Surface Modification of Nylon:
BEA-HBr can be employed as an alkylating agent for the surface modification of nylon to obtain primary, secondary, or tertiary amine groups. This modification enhances the properties of nylon, making it suitable for a broader range of applications.
Preparation
2-Bromoethylamine hydrobromide was synthesized by bromination of ethanolamine. Drop into hydrobromic acid in the reaction pot, cool, add ethanolamine dropwise under stirring, and finish adding dropwise within half an hour, then steam the hydrobromic acid of 85% of the input quantity (the feed quantity of hydrobromic acid is 8.89 times the weight of ethanolamine) , about 20h steamed. After the concentrated solution is cooled to 70-80°C, it is put into pre-chilled acetone, cooled to below 5°C, and the crystallized 2-bromoethylamine hydrobromide is filtered out. Yield 70%.
Air & Water Reactions
Water soluble.
Reactivity Profile
The acidic organic salt (HBr) of the amine. Acidic salts are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition 2-Bromoethylamine hydrobromide emits very toxic fumes of bromide ion, NOx and hydrogen bromide.
Fire Hazard
Flash point data for 2-Bromoethylamine hydrobromide are not available; however, 2-Bromoethylamine hydrobromide is probably combustible.
Check Digit Verification of cas no
The CAS Registry Mumber 2576-47-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,5,7 and 6 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 2576-47:
(6*2)+(5*5)+(4*7)+(3*6)+(2*4)+(1*7)=98
98 % 10 = 8
So 2576-47-8 is a valid CAS Registry Number.
InChI:InChI=1/C8H16N2/c1-3-6-10(7-4-2)8-5-9/h3-4H,1-2,5-9H2
2576-47-8Relevant articles and documents
New compound Malabemide, preparation method and uses thereof
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Paragraph 0024; 0025-0026, (2018/11/03)
The invention discloses a new compound Malabemide with a molecule formula represented by a formula h, a preparation method and pharmaceutical applications thereof, wherein ethanolamine and 5-chloro-2-pyridinecarboxylic acid are used as starting raw materials, corresponding intermediates 2-bromoethylamine hydrobromide and 5-chloro-2-pyridinecarbonyl chloride are respectively synthesized, and are subjected to a reaction to generate 5-chloro-N-(2-bromoethyl)-2-pyridinecarboxamide, and the 5-chloro-N-(2-bromoethyl)-2-pyridinecarboxamide and morpholine are subjected to condensation to generate Malabemide h. According to the present invention, the preparation method has characteristics of easily available raw materials, simple operation, good product purity and high yield, and is suitable for industrial production. The formula h is defined in the specification.
Studies on the chemistry of aziridine boranes.
Akerfeldt,Wahlberg,Hellstr?m
, p. 115 - 125 (2007/10/16)
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