25193-95-7

Basic information

• Product Name: 5-Pyrimidinemethanol
• Synonyms: RARECHEM AK ML 0566;PYRIMIDIN-5-YLMETHANOL;5-pyrimidinemethanol;5-(HYDROXYMETHYL)PYRIMIDINE;5-Pyrimidinemethanol (7CI,9CI);(PYRIMIDIN-5-YL)METHANOL,PURITY:95% MIN(HPLC);5-(Hydroxymethyl)pyrimidi...
• CAS NO: 25193-95-7
• Molecular Formula: C₅H₆N₂O
• Molecular Weight: 110.11
• Product Categories: PYRIMIDINE;pharmacetical;Heterocycle-Pyrimidine series
• Mol File: 25193-95-7.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 250.784 °C at 760 mmHg
• Flash Point: 105.47 °C
• Appearance: /
• Density: 1.228 g/cm³
• Vapor Pressure: 0.011mmHg at 25°C
• Refractive Index: 1.557
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 5-Pyrimidinemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Pyrimidinemethanol(25193-95-7)
• EPA Substance Registry System: 5-Pyrimidinemethanol(25193-95-7)

Safety Data

• Hazardous Substances Data: 25193-95-7(Hazardous Substances Data)

Usage

Description

5-Pyrimidinemethanol is an organic compound with the molecular formula C5H5N2O. It is a versatile reagent used in the synthesis of various chemical compounds and has potential applications in the pharmaceutical industry due to its unique chemical properties.

Uses

Used in Pharmaceutical Industry:
5-Pyrimidinemethanol is used as a reagent for the synthesis of melanin-concentrating hormone receptor 1 (MCHR1) antagonists. These antagonists have potential applications in the treatment of various disorders, such as obesity and anxiety, by modulating the activity of MCHR1 receptors in the body.
Used in Organic Chemistry:
5-Pyrimidinemethanol is also used in the preparation of annulated 5-aryl-substituted pyridines, which are important intermediates in the synthesis of various pharmaceutical compounds and organic molecules. The annulation process involves the formation of a ring structure by connecting two or more atoms, which can enhance the stability and reactivity of the resulting compounds.

InChI:InChI=1/C5H6N2O/c8-3-5-1-6-4-7-2-5/h1-2,4,8H,3H2

Upstream product

• 40929-50-8 ethyl pyrimidine-5-carboxylate 
• 10070-92-5 pyrimidine-5-carbaldehyde 

Downstream Products

• 144164-23-8 carbonic acid 4-nitro-phenyl ester pyrimidin-5-ylmethyl ester 
• 1141080-80-9 pyrimidin-5-ylmethyl 4-methylbenzenesulfonate 
• 1450723-44-0 N-[(4-morpholinosulfonylphenyl)methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide 
• 147740-04-3 ethyl 1H,2H,3H-pyrrolo[3,4-c]pyridine-2-carboxylate 
• 496-13-9 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine 
• 1454251-17-2 1,3-dihydropyrrolo[3,4-c]pyridin-2-carboxylic acid [5-(3-trifluoromethylbenzenesulfonyl)pyridin-2-ylmethyl]amide 
• 126230-78-2 5-(2-Propynyloxymethyl)pyrimidine 
• 25198-96-3 5-(bromomethyl)pyrimidine 
• 25198-95-2 (pyrimidin‐5‐yl)methanamine 
• 1383916-51-5 N-[(5-pyrimidinyl)methyl]-2-pyridinamine 
• 10070-92-5 pyrimidine-5-carbaldehyde 

Relevant articles and documents

Investigation of liver alcohol dehydrogenase catalysis using an NADH biomimetic and comparison with a synthetic zinc model complex

We have compared the catalytic activity of horse liver alcohol dehydrogenase (LADH) with a synthetic zinc model complex in the presence of N-benzyl-1,4-dihydronicotinamide (BNAH), a cofactor which serves as a biomimetic for the natural cofactor NADH. We have used five different substrates (benzaldehyde, p-anisaldehyde, 4-nitrobenzaldehyde, 2-pyridine carboxaldehyde, and 5-pyrimidine carboxaldehyde) in this study. These substrates vary in their substituent inductive effect, which is the ability to donate or withdraw electron density away from their carbonyl-functional group. Our results reveal that in the presence of NADH, geometric factors (induced fit of the substrate and cofactor in the enzyme active site) are vital. However, reactivity assays show that in the presence of BNAH, there is a strong correlation between substrate electronic environment and the observed catalytic rate, i.e. the more electron withdrawn the substrate, the greater the speed at which the reduction reaction occurs. NMR spectroscopy reveals that a synthetic zinc model complex catalyzes the reduction of substrates in a manner consistent with LADH enzyme.

Controlled meta-Selective C-H Mono- And Di-Olefination of Mandelic Acid Derivatives

Mandelic acids represent a key structural motif present in many drug molecules. Herein, we report the controlled meta-selective mono- and diolefination of mandelic acids by the careful design of the substrate and oxidant. Furthermore, free meta-functional

cGAS ANTAGONIST COMPOUNDS

Disclosed are novel compounds of Formula (I) that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.