25198-96-3

Basic information

• Product Name: Pyrimidine, 5-(bromomethyl)- (8CI,9CI)
• Synonyms: Pyrimidine, 5-(bromomethyl)- (8CI,9CI);Pyrimidine, 5-(Bromomethyl)-;5-BroMoMethyl-PyriMidine HBr
• CAS NO: 25198-96-3
• Molecular Formula: C₅H₅BrN₂
• Molecular Weight: 173.0106
• Product Categories: PYRIMIDINE
• Mol File: 25198-96-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 232.6±15.0 °C(Predicted)
• Appearance: /
• Density: 1.641±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 1.61±0.10(Predicted)
• CAS DataBase Reference: Pyrimidine, 5-(bromomethyl)- (8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimidine, 5-(bromomethyl)- (8CI,9CI)(25198-96-3)
• EPA Substance Registry System: Pyrimidine, 5-(bromomethyl)- (8CI,9CI)(25198-96-3)

Safety Data

• Hazardous Substances Data: 25198-96-3(Hazardous Substances Data)

Usage

General Description

Pyrimidine, 5-(bromomethyl)- (8CI,9CI) is a chemical compound classified under organic compounds known particularly as Pyrimidines and derivatives. Its systematic name is thus 5-(Bromomethyl)pyrimidine and it mainly contains elements of carbon, hydrogen, nitrogen, and bromine. This chemical compound features in various scientific research fields, particularly in those concerned with the synthesis of new materials or other chemical compounds. Its particular characteristics, such as its reactivity, make it valuable in this context. However, like many other chemical compounds, it should be handled with care as exposure may potentially lead to harmful effects, especially eye, skin, or respiratory irritation. Specific safety data and handling instructions should always be consulted prior to working with such chemicals.

Upstream product

• 2036-41-1 5-methylpyrimidine 
• 25193-95-7 5-(hydroxymethyl)pyrimidine 

Downstream Products

• 1383916-51-5 N-[(5-pyrimidinyl)methyl]-2-pyridinamine 

Relevant articles and documents

A N - 2 - pyridine -5 - pyrimidine preparation of method (by machine translation)

The invention belongs to the technical field of agricultural chemical intermediates, in particular to a N - 2 - pyridine - 5 - pyrimidine preparation of method. The preparation method is to cheap and easily obtained 3 - ethoxy - 2 - methyl acrolein as the starting material, with 25% ammonia reaction, to obtain 3 - amino - 2 - methyl acrolein; then with the formamide cyclized, to obtain 5 - methyl pyrimidine; in a carbon tetrachloride solution N - bromo succinimide bromide to obtain 5 - bromo methyl pyrimidine; then under the action of the triethylamine, with 2 - aminopyridine reaction to obtain N - 2 - pyridine - 5 - pyrimidine methylamine. The invention realized through designing a brand new N - 2 - pyridine - 5 pyrimidine methylamine preparation process route, in order to 3 - ethoxy - 2 - methyl acrolein as the starting material, through the ammoniation, cyclization, to obtain the bromide 5 - bromo methyl pyrimidine, then with 2 - aminopyridine reaction to obtain the target product; this invention adopts the cheap and easy to obtain 3 - ethoxy acrolein, in conventional process compared with the use of expensive 5 - pyrimidine formaldehyde, and greatly reduces the production cost. (by machine translation)

BIARYL PYRAZOLES AS NRF2 REGULATORS

The present invention relates to biaryl pyrazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.

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The invention is related to compounds of Formula (I), (II), or (III): or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.