25195-52-2

Basic information

• Product Name: 1-bromo-2-(methylsulfonylmethyl)benzene
• Synonyms: 1-bromo-2-(methylsulfonylmethyl)benzene;1-broMo-2-(MethanesulfonylMethyl)benzene
• CAS NO: 25195-52-2
• Molecular Formula: C₈H₉BrO₂S
• Molecular Weight: 249.127
• Mol File: 25195-52-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 403.2°C at 760 mmHg
• Flash Point: 197.7°C
• Appearance: /
• Density: 1.562g/cm³
• Vapor Pressure: 2.41E-06mmHg at 25°C
• Refractive Index: 1.573
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-bromo-2-(methylsulfonylmethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-bromo-2-(methylsulfonylmethyl)benzene(25195-52-2)
• EPA Substance Registry System: 1-bromo-2-(methylsulfonylmethyl)benzene(25195-52-2)

Safety Data

• Hazardous Substances Data: 25195-52-2(Hazardous Substances Data)

Usage

General Description

1-bromo-2-(methylsulfonylmethyl)benzene is a chemical compound identified by the CAS number 660383-12-9. It is part of the benzene and substituted derivatives group of chemicals. This chemical is primarily utilized in laboratory or scientific research, commonly as an organic synthons or reagents in organic chemistry. It belongs to the family of bromobenzenes and does not have any predominant applications in industrial production. Its properties such as molecular structure, stability, and reactivity can be further understood through various analytical methods in the chemical studies. Caution is recommended in handling this compound due to its potential reactivity.

InChI:InChI=1/C8H9BrO2S/c1-12(10,11)6-7-4-2-3-5-8(7)9/h2-5H,6H2,1H3

Upstream product

• 20277-69-4 sodium methansulfinate 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 113283-03-7 2-bromo-α-toluenesulfonamide 
• 74-88-4 methyl iodide 

Downstream Products

• 1402602-00-9 methyl 3-(2-fluoro-4-((2-((methylsulfonyl)methyl)phenyl)ethynyl)phenyl)propanoate 
• 1402601-84-6 3-(2-fluoro-4-((2-((methylsulfonyl)methyl)phenyl)ethynyl)phenyl)propanoic acid 

Relevant articles and documents

NHC-Catalyzed Deamination of Primary Sulfonamides: A Platform for Late-Stage Functionalization

Herein we describe the development and application of a method for the mild, late-stage conversion of primary sulfonamides to several other other functional groups. These reactions occur via initial reductive deamination of sulfonamides to sulfinates via an NHC-catalyzed reaction of transiently formed N-sulfonylimines. The method described here is tolerant of nearly all common functional groups, as exemplified by the late-stage derivatization of several complex pharmaceutical compounds. On the basis of the prevalence of sulfonamide-containing drugs and building blocks, we have developed a method to enable sulfonamides to be applied as versatile synthetic handles for synthetic chemsitry.

ORTHO-FLUORO SUBSTITUTED COMPOUNDS FOR THE TREATMENT OF METABOLIC DISEASES

There is provided novel fluoro-substituted compounds capable of modulating the G- protein-coupled receptor GPR40, compositions comprising the compounds, and methods for their use for controlling insulin levels in vivo and for the treatment of conditions such as type II diabetes, hypertension, ketoacidosis, obesity, glucose intolerance, and hypercholesterolemia and related disorders associated with abnormally high or low plasma lipoprotein, triglyceride or glucose levels.