1402601-84-6

Basic information

• Product Name: 3-(2-fluoro-4-((2-((methylsulfonyl)methyl)phenyl)ethynyl)phenyl)propanoic acid
• Synonyms: 3-(2-fluoro-4-((2-((methylsulfonyl)methyl)phenyl)ethynyl)phenyl)propanoic acid
• CAS NO: 1402601-84-6
• Molecular Weight: 360.406
• Mol File: 1402601-84-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(2-fluoro-4-((2-((methylsulfonyl)methyl)phenyl)ethynyl)phenyl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-fluoro-4-((2-((methylsulfonyl)methyl)phenyl)ethynyl)phenyl)propanoic acid(1402601-84-6)
• EPA Substance Registry System: 3-(2-fluoro-4-((2-((methylsulfonyl)methyl)phenyl)ethynyl)phenyl)propanoic acid(1402601-84-6)

Safety Data

• Hazardous Substances Data: 1402601-84-6(Hazardous Substances Data)

Upstream product

• 1402602-00-9 methyl 3-(2-fluoro-4-((2-((methylsulfonyl)methyl)phenyl)ethynyl)phenyl)propanoate 
• 25195-52-2 1-bromo-2-((methylsulfonyl)methyl)benzene 
• 1402601-93-7 methyl 3-(4-ethynyl-2-fluorophenyl)propanoate 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 1057674-14-2 ethyl 3-(4-bromo-2-fluorophenyl)propanoate 
• 581778-88-3 (E)-ethyl 3-(4-bromo-2-fluorophenyl)acrylate 
• 57848-46-1 4-bromo-2-fluorobenzaldehyde 

Relevant articles and documents

Discovery of TUG-770: A highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist for treatment of type 2 diabetes

Free fatty acid receptor 1 (FFA1 or GPR40) enhances glucose-stimulated insulin secretion from pancreatic β-cells and currently attracts high interest as a new target for the treatment of type 2 diabetes. We here report the discovery of a highly potent FFA1 agonist with favorable physicochemical and pharmacokinetic properties. The compound efficiently normalizes glucose tolerance in diet-induced obese mice, an effect that is fully sustained after 29 days of chronic dosing.