251986-49-9

Basic information

• Product Name: methyl 3-carbomethoxy-3-(4'-fluorophenyl)amino-2-propenoate
• Synonyms: methyl 3-carbomethoxy-3-(4'-fluorophenyl)amino-2-propenoate
• CAS NO: 251986-49-9
• Molecular Weight: 253.23
• Mol File: 251986-49-9.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: methyl 3-carbomethoxy-3-(4'-fluorophenyl)amino-2-propenoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-carbomethoxy-3-(4'-fluorophenyl)amino-2-propenoate(251986-49-9)
• EPA Substance Registry System: methyl 3-carbomethoxy-3-(4'-fluorophenyl)amino-2-propenoate(251986-49-9)

Safety Data

• Hazardous Substances Data: 251986-49-9(Hazardous Substances Data)

Upstream product

• 762-42-5 dimethyl acetylenedicarboxylate 
• 371-40-4 4-fluoroaniline 

Downstream Products

• 1169473-89-5 dimethyl 1,3-bis(4-fluorophenyl)-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylate 
• 1613024-37-5 3-(4-fluorophenylamino)-1-methyl-1H-pyrrole-2,5-dione 
• 1613024-73-9 3-benzyl-1-(4-fluorophenyl)-6-methyl-4-phenyl-1,2,3,4-tetrahydro-6H-pyrrolo[3,4-d]pyrimidine-5,7-dione 
• 1613024-68-2 3,6-dimethyl-1-(4-fluorophenyl)-4-phenyl-1,2,3,4-tetrahydro-6H-pyrrolo[3,4-d]pyrimidine-5,7-dione 
• 1613024-67-1 3,4-diphenyl-1-(4-fluorophenyl)-6-methyl-1,2,3,4-tetrahydro-6H-pyrrolo[3,4-d]pyrimidine-5,7-dione 
• 1613024-53-5 3-benzyl-1-(4-iodophenyl)-6-methyl-1,2,3,4-tetrahydro-6H-pyrrolo[3,4-d]pyrimidine-5,7-dione 
• 1613024-58-0 1-(4-fluorophenyl)-6-methyl-3-(2-morpholinoethyl)-1,2,3,4-tetrahydro-6H-pyrrolo[3,4-d]pyrimidine-5,7-dione 
• 1443430-34-9 methyl 1-(4-fluorophenyl)-4-((4-fluorophenyl)amino)-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylate 
• 343-10-2 6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 251986-57-9 4,5-dimethoxycarbonyl-1-(4'-fluorophenyl)-1H-pyrrole-2,3-dione 

Relevant articles and documents

A synthesis of 4-quinolone-3-carboxylic acids via pyrolysis of N- aryldioxopyrrolines

A synthesis of 4-quinolone-3-carboxylic acids (8) was achieved by pyrolysis of 4,5-dimethoxycarbonyl-1-aryl-1H-pyrrole-2,3-diones (3) followed by selective demethoxycarbonylation of the resulting 2,3-dimethoxycarbonyl-4- quinolones (4) in excellent overall yields.

Copper-Catalyzed Three-Component Cascade Michael Addition/Heck-Type Alkylation/Annulation: Accessing Fully Substituted 1,3-Dihydro-2 H-pyrrol-2-ones

We report a highly efficient copper-catalyzed three-component reaction of alkylamines, acetylenedicarboxylates, and α-bromocarbonyls for the assembly of fully substituted 1,3-dihydro-2H-pyrrol-2-ones. A variety of alkylamines and ammonium salt are functionalized with acetylenedicarboxylates and α-bromocarbonyls. N-aryl enaminoesters are also successfully alkylated with α-bromocarbonyls. This protocol is understood to proceed through radical Heck-type coupling of in-situ-generated bulky trisubstituted alkenes with bulky tertiary alkyl bromides, which is realized for the first time.

Trifluoroacetic acid catalyzed one-pot four-component domino reaction for the synthesis of substituted dihydro 2-oxypyrroles

Trifluoroacetic acid was applied as an effcient catalyst for the one-pot four-component synthesis of N-aryl/alkyl-3-aminodihydropyrrol-2-one-4-carboxylates via the domino reaction of amines, formaldehyde and dialkyl acetylenedicarboxylates at ambient temp