252881-74-6 Usage
Description
TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA, also known as Amino-PEG3-t-butyl ester, is a PEG (polyethylene glycol) linker containing an amino group with a t-butyl protected carboxyl group. This molecule is characterized by its hydrophilic PEG spacer, which enhances solubility in aqueous media, and its reactive amino group that can interact with various functional groups such as carboxylic acids, activated NHS esters, and carbonyls. The t-butyl protected carboxyl group can be deprotected under acidic conditions, making it a versatile component in bioconjugate chemistry.
Uses
Used in Pharmaceutical Industry:
TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA is used as a spacer or linker for the synthesis of various pharmaceutical compounds, including:
1. Tetanus-toxin conjugate of MUC1 glycopeptide antigen, which serves as a potential antitumor vaccine.
2. Self-assembled monolayer-based surface-enhanced raman scattering (SERS) labels for immuno-SERS microscopy, enhancing the detection and analysis of biological samples.
3. Polycationic adamantane-based dendrons for cell imaging, allowing for improved visualization and understanding of cellular structures and processes.
4. Phthalocyanine (Pc)-peptide conjugates as potential fluorescence imaging agents for cancers overexpressing epidermal growth factor receptors (EGFR), aiding in the identification and targeting of cancer cells.
These applications highlight the importance of TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA in the development of innovative pharmaceutical products and diagnostic tools, contributing to advancements in healthcare and medical research.
Check Digit Verification of cas no
The CAS Registry Mumber 252881-74-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,2,8,8 and 1 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 252881-74:
(8*2)+(7*5)+(6*2)+(5*8)+(4*8)+(3*1)+(2*7)+(1*4)=156
156 % 10 = 6
So 252881-74-6 is a valid CAS Registry Number.
InChI:InChI=1/C13H26O6/c1-13(2,3)19-12(15)4-6-16-8-10-18-11-9-17-7-5-14/h14H,4-11H2,1-3H3
252881-74-6Relevant articles and documents
CONJUGATES OF A CELL-BINDING MOLECULE WITH CAMPTOTHECIN ANALOGS
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, (2021/10/30)
Provided are conjugates of camptothecin analogs with a cell-binding molecule of formula (I), wherein R1, R2, R3, R4, R5, X, L, n, m, T and ----- are defined herein. It also provides methods of making the conjugates of camptothecin analogs to a cell-binding agent, as well as methods of using the conjugates in targeted treatment of cancer, infection, and immunological disorders.
CONJUGATION LINKERS CONTAINING 2,3-DIAMINOSUCCINYL GROUP
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, (2020/05/19)
Provided is a conjugate of a cytotoxic drug/molecule to a cell-binding molecule with a bis-linker (adual-linker) containing a 2, 3-diaminosuccinyl group. It also relates to preparation of the conjugate of a cytotoxic drug/molecule to a cell-binding molecule with the bis-linker, particularly when the drug having functional groups of amino, hydroxyl, diamino, amino-hydroxyl, dihydroxyl, carboxyl, hydrazine, aldehyde and thiol for conjugation with the bis-linker in a specific manner, as well as the therapeutic use of the conjugates.
A CONJUGATE OF A CYTOTOXIC AGENT TO A CELL BINDING MOLECULE WITH BRANCHED LINKERS
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, (2021/01/23)
Provided is a conjugation of cytotoxic drug to a cell-binding molecule with a side-chain linker. It provides side-chain linkage methods of making a conjugate of a cytotoxic molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and immunological disorders.
