253350-39-9

Basic information

• Product Name: 3-(S)-t-butyldimethylsilyloxy-4-(3-methoxymethylphenyl)-1-butyne
• Synonyms: 3-(S)-t-butyldimethylsilyloxy-4-(3-methoxymethylphenyl)-1-butyne
• CAS NO: 253350-39-9
• Molecular Weight: 304.505
• Mol File: 253350-39-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(S)-t-butyldimethylsilyloxy-4-(3-methoxymethylphenyl)-1-butyne(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(S)-t-butyldimethylsilyloxy-4-(3-methoxymethylphenyl)-1-butyne(253350-39-9)
• EPA Substance Registry System: 3-(S)-t-butyldimethylsilyloxy-4-(3-methoxymethylphenyl)-1-butyne(253350-39-9)

Safety Data

• Hazardous Substances Data: 253350-39-9(Hazardous Substances Data)

Upstream product

• 253350-30-0 (2S)-3-(3-methoxymethylphenyl)-1-triphenylmethoxypropan-2-ol 
• 253350-33-3 1-acetoxy-3-(3-methoxymethylphenyl)-2-(S)-tetrahydropyranyloxypropane 
• 253350-36-6 1,1-dibromo-3-(S)-tetrahydropyranyloxy-4-(3-methoxymethylphenyl)-1-butene 
• 253350-34-4 2-(S)-tetrahydropyranyloxy-3-(3-methoxymethylphenyl)propan-1-ol 
• 253350-35-5 2-(S)-tetrahydropyranyloxy-3-(3-methoxymethylphenyl)propan-1-al 
• 253350-32-2 (2S)-3-(3-methoxymethylphenyl)-1-acetyloxypropan-2-ol 
• 253350-31-1 (2S)-3-(3-methoxymethylphenyl)propan-1,2-diol 
• 1515-89-5 3-(methoxymethyl)bromobenzene 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 253350-38-8 (3S)-4-(3-methoxymethylphenyl)-1-butyn-3-ol 

Downstream Products

• 256382-23-7 5-thia-16-(3-methoxymethylphenyl)methylPGE₁ 
• 261772-02-5 (Z)-7-{(1R,2R,3R)-3-Hydroxy-2-[(E)-(S)-3-hydroxy-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-oxo-cyclopentyl}-hept-5-enoic acid methyl ester 
• 256382-08-8 Rivenprost 
• 261772-01-4 7-{(1R,2R,3R)-3-Hydroxy-2-[(E)-(S)-3-hydroxy-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-oxo-cyclopentyl}-heptanoic acid methyl ester 
• 443147-10-2 (Z)-7-{(1R,2R,3R,5R)-5-Chloro-3-hydroxy-2-[(E)-(S)-3-hydroxy-4-(3-methoxymethyl-phenyl)-but-1-enyl]-cyclopentyl}-hept-5-enoic acid methyl ester 
• 261772-72-9 7-{(1R,2R,3R,5R)-5-Chloro-3-hydroxy-2-[(E)-(S)-3-hydroxy-4-(3-methoxymethyl-phenyl)-but-1-enyl]-cyclopentyl}-heptanoic acid methyl ester 
• 443147-11-3 (Z)-7-{(1R,2R,3R,5R)-5-Fluoro-3-hydroxy-2-[(E)-(S)-3-hydroxy-4-(3-methoxymethyl-phenyl)-but-1-enyl]-cyclopentyl}-hept-5-enoic acid methyl ester 
• 256382-35-1 4-{2-[(2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-oxo-cyclopent-(E)-ylidene]-ethylsulfanyl}-butyric acid methyl ester 
• 256382-36-2 methyl 4-({2-[(1R,2R,3S)-3-{[dimethyl(2-methyl-2-propanyl)silyl]-oxy}-2-{(1E,3S)-3-{[dimethyl(2-methyl-2-propanyl)silyl]oxy}-4-[3-(methoxymethyl)phenyl]-1-buten-1-yl}-5-oxocyclopentyl]ethyl}sulfanyl)-butanoate 
• 443147-08-8 (Z)-7-{(1R,2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-oxo-cyclopentyl}-hept-5-enoic acid methyl ester 
• 256382-34-0 4-(2-{(2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-oxo-cyclopentyl}-2-hydroxy-ethylsulfanyl)-butyric acid methyl ester 
• 443147-09-9 (Z)-7-{(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-hydroxy-cyclopentyl}-hept-5-enoic acid methyl ester 
• 261772-00-3 7-{(1R,2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-oxo-cyclopentyl}-heptanoic acid methyl ester 
• 261772-69-4 7-{(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-hydroxy-cyclopentyl}-heptanoic acid methyl ester 

Relevant articles and documents

Design and synthesis of a selective EP4-receptor agonist. Part 3: 16-phenyl-5-thiaPGE(1) and 9-beta-halo derivatives with improved stability.

To identify a new selective EP4-agonist with improved chemical stability, further chemical modification of those reported previously was continued. We focused our attention on chemical modification of the alpha chain of 3,7-dithiaPGE(1) and selected 5-thi