253609-31-3

Basic information

• Product Name: (1'R,1''R,2S,5''R)-2-[phenyl-1'-(2''-azabicyclo[3.3.0]octane-2''-yl)methyl]-1,2,3,4-tetrahydro-1-naphthalinone
• Synonyms: (1'R,1''R,2S,5''R)-2-[phenyl-1'-(2''-azabicyclo[3.3.0]octane-2''-yl)methyl]-1,2,3,4-tetrahydro-1-naphthalinone
• CAS NO: 253609-31-3
• Molecular Weight: 345.484
• Mol File: 253609-31-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1'R,1''R,2S,5''R)-2-[phenyl-1'-(2''-azabicyclo[3.3.0]octane-2''-yl)methyl]-1,2,3,4-tetrahydro-1-naphthalinone(CAS DataBase Reference)
• NIST Chemistry Reference: (1'R,1''R,2S,5''R)-2-[phenyl-1'-(2''-azabicyclo[3.3.0]octane-2''-yl)methyl]-1,2,3,4-tetrahydro-1-naphthalinone(253609-31-3)
• EPA Substance Registry System: (1'R,1''R,2S,5''R)-2-[phenyl-1'-(2''-azabicyclo[3.3.0]octane-2''-yl)methyl]-1,2,3,4-tetrahydro-1-naphthalinone(253609-31-3)

Safety Data

• Hazardous Substances Data: 253609-31-3(Hazardous Substances Data)

Upstream product

• 156473-27-7 (3aR,6aR)-octahydrocyclopentapyrrole 
• 7007-34-3 1-(3,4-dihydro-1-naphthalenyl)pyrrolidine 

Downstream Products

• 6261-33-2 (1R,2S)-2-benzyl-1,2,3,4-tetrahydronaphthalen-1-ol 
• 6261-33-2 trans-2-benzyl-1,2,3,4-tetrahydronaphthalen-1-ol 
• 253609-34-6 (1R,1'R,1''R,2S,5''R)-2-[phenyl-1'-(2''-azabicyclo[3.3.0]octane-2''-yl)methyl]-1,2,3,4-tetrahydro-1-naphthalinol 
• 253609-35-7 (1S,1'R,1''R,2S,5''R)-2-[phenyl-1'-(2''-azabicyclo[3.3.0]octane-2''-yl)methyl]-1,2,3,4-tetrahydro-1-naphthalinol 

Relevant articles and documents

Highly stereoselective synthesis of 1,3-aminoalcohols via Mannich reactions

Diastereoselective synthesis of β-amino ketones by a one-pot Mannich reaction and their subsequent reduction afforded sterically congested enantiomerically pure 1,3-aminoalcohols in high diastereoselectivity: dr up to >98:2 over two steps. The absolute configurations of the newly created stereogenic centers were assigned by NMR spectroscopy and chemical correlation.