6261-33-2

Basic information

• Product Name: trans-2-benzyl-1,2,3,4-tetrahydronaphthalene-1-ol
• CAS NO: 6261-33-2
• Molecular Weight: 238.329
• Mol File: 6261-33-2.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: trans-2-benzyl-1,2,3,4-tetrahydronaphthalene-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: trans-2-benzyl-1,2,3,4-tetrahydronaphthalene-1-ol(6261-33-2)
• EPA Substance Registry System: trans-2-benzyl-1,2,3,4-tetrahydronaphthalene-1-ol(6261-33-2)

Safety Data

• Hazardous Substances Data: 6261-33-2(Hazardous Substances Data)

Upstream product

• 529-33-9 1,2,3,4-Tetrahydro-1-naphthol 
• 100-51-6 benzyl alcohol 
• 100-52-7 benzaldehyde 
• 6261-32-1 (E)-2-benzylidene-1-tetralone 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 6261-31-0 2-benzylidene-1-tetralol 
• 253609-31-3 (1'R,1''R,2S,5''R)-2-[phenyl-1'-(2''-azabicyclo[3.3.0]octane-2''-yl)methyl]-1,2,3,4-tetrahydro-1-naphthalinone 
• 7007-34-3 1-(3,4-dihydro-1-naphthalenyl)pyrrolidine 
• 253609-34-6 (1R,1'R,1''R,2S,5''R)-2-[phenyl-1'-(2''-azabicyclo[3.3.0]octane-2''-yl)methyl]-1,2,3,4-tetrahydro-1-naphthalinol 
• 6261-32-1 2-benzylidene-1-tetralone 
• 91-01-0 1,1-Diphenylmethanol 
• 132797-26-3 2-benzyl-1-tetralone 
• 253609-35-7 (1S,1'R,1''R,2S,5''R)-2-[phenyl-1'-(2''-azabicyclo[3.3.0]octane-2''-yl)methyl]-1,2,3,4-tetrahydro-1-naphthalinol 

Downstream Products

• 129113-12-8 2Z-benzylidene-1,2,3,4-tetrahydronaphthalene 
• 129113-11-7 2-benzyl-1,4-dihydronaphthalene 
• 613-59-2 2-benzylnaphthalene 
• 157485-34-2 (S)-2-benzyl-1-tetralone 
• 78140-79-1 trans-2-benzyl-1,2,3,4-tetrahydronaphthalene-1-ol acetate 
• 27019-11-0 3-benzyl-1,2-dihydronaphthalene 

Relevant articles and documents

Asymmetric Hydrogenation of Racemic Allylic Alcohols via an Isomerization-Dynamic Kinetic Resolution Cascade

Prochiral racemic allylic alcohols are converted to enantioenriched chiral alcohols bearing adjacent stereocenters catalyzed by a diamine diphosphine Ru complex in the presence of tBuOK. The protocol features a broad substrate scope (56 examples) and high

Switchable β-alkylation of secondary alcohols with primary alcohols by a well-defined cobalt catalyst

β-alkylation of secondary alcohols with primary alcohols to selectively generate alcohols by a well-defined Co catalyst is presented. Remarkably, a low catalyst loading of 0.7 mol % can be employed for the reaction. More significantly, this study represents the first Co-catalyzed switchable alcohol/ketone synthesis by simply manipulating the reaction parameters. In addition, the transformation is environmentally friendly, with water as the only byproduct.

Isomerization-Asymmetric Hydrogenation Sequence Converting Racemic β-Ylidenecycloalkanols into Stereocontrolled β-Substituted Cycloalkanols Using a Ru Catalytic System with Dual Roles

Racemic β-ylidenecycloalkanols were transformed into the cis-β-substituted cycloalkanols with high enantio- and diastereoselectivities through an isomerization-asymmetric hydrogenation sequence with the (4,4′-bi-1,3-benzodioxole)-5,5′-diylbis[di(3,5-xylyl)phosphine (DM-Segphos)/2-dimethylamino-1-phenylethylamine (DMAPEN)-ruthenium(II) catalyst; such transformation hardly proceeded by single-step asymmetric hydrogenation. The reaction was usually carried out with a substrate-to-catalyst molar ratio of 500 under 4 to 10 atm of H2 to afford the products in cis/trans ratio up to 99:1 and 98% ee. Mechanistic experiments suggested that this catalytic system reversibly formed two reactive species, types (I) and (II), through a ruthenacyclic amide intermediate. The amide complex and allylic alcohol reacted to afford the allylic alkoxide complex with partial or full removal of diamine (type (I)), and this type (I) complex catalyzed isomerization of the allylic alcohols into the racemic α-substituted ketones. The RuH2 complex with chelation of diamine (type (II)) formed by reaction of the amide complex and hydrogen promoted asymmetric hydrogenation of racemic α-substituted ketone into the stereocontrolled β-substituted cycloalkanols through dynamic kinetic resolution. (Figure presented.).