25373-61-9

Basic information

• Product Name: 1-[2-nitro-4-(trifluoromethyl)phenyl]-1H-imidazole
• Synonyms: 1-[2-nitro-4-(trifluoromethyl)phenyl]-1H-imidazole;1-[2-nitro-4-(trifluoromethyl)phenyl]imidazole
• CAS NO: 25373-61-9
• Molecular Formula: C₁₀H₆F₃N₃O₂
• Molecular Weight: 257.1687496
• Mol File: 25373-61-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-[2-nitro-4-(trifluoromethyl)phenyl]-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-nitro-4-(trifluoromethyl)phenyl]-1H-imidazole(25373-61-9)
• EPA Substance Registry System: 1-[2-nitro-4-(trifluoromethyl)phenyl]-1H-imidazole(25373-61-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 25373-61-9(Hazardous Substances Data)

Usage

Chemical class

Imidazole compounds

Molecular weight

249.16 g/mol

Structure

Nitro derivative of 4-(trifluoromethyl)phenyl-imidazole

Applications

Pharmaceutical and agrochemical industries

Building block

Synthesis of various organic compounds

Biological activity

Potential antifungal, antibacterial, and antiparasitic agent

Additional study

Potential use as a photoinitiator in polymerization processes

Fields of application

Medicine, agriculture, and material science

Upstream product

• 288-32-4 1H-imidazole 
• 121-17-5 2-chloro-3-nitro-5-trifluoromethylbenzene 
• 367-86-2 1-fluoro-2-nitro-4-trifluoromethyl-benzene 

Downstream Products

• 380389-65-1 1-(4-chlorophenylcarboxamido)-2-(1H-1-imidazolyl)-5-trifluoromethylbenzene 
• 420849-27-0 5-(4-chlorobenzoyl)-4-bromo-7-trifluoromethyl-4,5-dihydrobenzo[e]imidazo[2,1-c][1,4,2]diazaphosphinine 
• 420849-29-2 5-(4-chlorobenzoyl)-4-phenyl-7-trifluoromethyl-4,5-dihydrobenzo[e]imidazo[2,1-c][1,4,2]diazaphosphinine 
• 380420-01-9 5-(4-chlorobenzoyl)-4-morpholino-4-thioxo-7-trifluoromethyl-4,5-dihydrobenzo[e]imidazo[2,1-c][1,4,2]diazaphosphinine 
• 1315610-14-0 ethyl 2-{1-[2-nitro-4-(trifluoromethyl)phenyl]-1H-imidazol-2-yl}-2-oxoacetate 
• 1060673-31-5 3-{[1-(4-methoxyphenyl)-7-(trifluoromethyl)imidazo[1,2-a]quinoxalin-4-yl]amino}propan-1-ol 
• 1060673-29-1 3-{4-[(3-hydroxypropyl)amino]-7-(trifluoromethyl)imidazo[1,2-a]quinoxalin-1-yl}benzenesulfonamide 
• 1060673-28-0 N-{3-[4-(3-Hydroxy-propylamino)-7-trifluoromethyl-imidazo[1,2-a]quinoxalin-1-yl]-phenyl}-acetamide 
• 1060673-62-2 3-({1-[3-(4-methoxyphenyl)-1H-pyrazol-5-yl]-7-(trifluoromethyl)imidazo[1,2-a]quinoxalin-4-yl}amino)propan-1-ol 

Relevant articles and documents

A catalytic intramolecular nitrene insertion into a copper(i)-N-heterocyclic carbene bond yielding fused nitrogen heterocycles

N-(2-Azidophenyl)azolium salts were easily prepared and reacted with copper(i) under conditions allowing the formation of NHC complexes. Under these conditions, the formation of benzimidazo-fused heterocycles occurred under catalytic, efficient and very mild conditions. This reaction is proposed to proceed via dinitrogen elimination and imido/nitrene-NHC cyclization.

Facile cuI-catalyzed arylation of azoles and amides using simple enaminones as efficient ligands

(E)-3-(Dimethylamino)-1-(2-hydroxyphenyl)prop-2-en-1-one was found to be an excellent ligand for copper-catalyzed N-arylation of azoles and amides with aryl halides under mild conditions. The reaction took place at 82 C in MeCN with broad functional-group compatibility. A combination of the ligand and CuI proved to be an efficient catalytic system to promote the coupling reactions of aryl halides with azoles and amides.

N,N′-(Phenylmethylene)diacetamide analogues as economical and efficient ligands in copper-catalyzed arylation of aromatic nitrogen-containing heterocycles

N,N′-(Phenylmethylene)diacetamide analogues which were simply prepared from the condensation reaction of an aldehyde with an amide or urea were found to be efficient ligands in copper-catalyzed coupling reaction of aryl halides with various azole nucleophiles. The newly developed ligand showed broad application scope in this conversion. Compounds including imidazoles, benzoimidazoles, pyrrole, indole, and benzotriazole were successfully arylated with diversified aromatic halides to give corresponding products in moderate to excellent yields. Georg Thieme Verlag Stuttgart.