254729-95-8

Basic information

• Product Name: 1H-Pyrrole-2-carbaldehyde
• Synonyms: 1H-PYRROLE-2-CARBALDEHYDE
• CAS NO: 254729-95-8
• Molecular Formula: C5H5NO
• Molecular Weight: 95.1
• EINECS: 213-705-5
• Mol File: 254729-95-8.mol
• Article Data: 83

Chemical Properties

• Melting Point: 40-47℃
• Boiling Point: 219.1°Cat760mmHg
• Flash Point: 107 °C
• Appearance: /
• Density: 1.197g/cm³
• Vapor Pressure: 0.121mmHg at 25°C
• Refractive Index: 1.607
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1H-Pyrrole-2-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-2-carbaldehyde(254729-95-8)
• EPA Substance Registry System: 1H-Pyrrole-2-carbaldehyde(254729-95-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 254729-95-8(Hazardous Substances Data)

Usage

General Description

1H-Pyrrole-2-carbaldehyde is a chemical compound with the chemical formula C6H5NO. It is an aromatic aldehyde that contains a pyrrole ring, which is a five-membered heterocyclic ring with nitrogen atoms. It is used as a building block in organic synthesis and can be used to create a variety of compounds. 1H-Pyrrole-2-carbaldehyde is a yellow liquid with a strong odor, and it is flammable and should be handled with care. It is commonly used in the production of pharmaceuticals, agrochemicals, and dyes. Additionally, it has potential applications in the field of materials science and nanotechnology.

InChI:InChI=1/C5H5NO/c7-4-5-2-1-3-6-5/h1-4,6H

Upstream product

• 65057-97-8 tetrahydro-2,5-dimethoxy-2-furaldehyde dimethyl acetal 
• 631-61-8 ammonium acetate 
• 109-97-7 pyrrole 
• 67-66-3 chloroform 
• 110-45-2 isopentyl formate 
• 68-12-2 N,N-dimethyl-formamide 
• 694-59-7 pyridine N-oxide 
• 109-89-7 diethylamine 
• 960622-17-7 (E)-pyrrole-2-carboxaldehyde oxime 
• 1478-41-7 diethoxycarbonium fluoroborate 
• 132407-64-8 trifluoromethanesulphonyloxy-methylene-N,N-dimethyliminium trifluoromethanesulphonate 
• 14479-37-9 N-((1H-pyrrol-2-yl)methylene)-4-methylbenzenamine 
• 83651-25-6 N-(pyrrolyl-2-methylene)-p-ethoxyaniline 
• 80525-78-6 N-((1H-pyrrol-2-yl)methylene)-4-methoxybenzenamine 

Downstream Products

• 102913-32-6 (Z)-4-((1H-pyrrol-2-yl)methylene)-2-phenyloxazol-5(4H)-one 
• 53428-07-2 5-pyrrol-2-ylmethylene-2-thioxo-thiazolidin-4-one 
• 103860-43-1 4-pyrrol-2-ylmethylenamino-phenol 
• 99970-01-1 1-benzoylpyrrole-2-carbaldehyde 
• 116055-66-4 benzoic acid-((Ξ)-pyrrol-2-ylidenemethyl ester) 
• 108540-62-1 2-(2,4-dichloro-phenyl)-2-hydroxy-1-pyrrol-2-yl-ethanone 
• 67973-63-1 2-hydroxy-4-pyrrol-2-ylmethylenamino-benzoic acid 
• 15072-08-9 (N¹E,N²E)-N¹,N²-bis((1H-pyrrol-2-yl)methylene)-benzene-1,2-diamine 
• 81280-72-0 pyrrole-2-carboxaldehyde phenylhydrazone 
• 92245-48-2 4-pyrrol-2-ylmethyleneamino-benzoic acid ethyl ester 
• 960622-17-7 (E)-pyrrole-2-carboxaldehyde oxime 
• 97125-09-2 (Z)-pyrrole-2-carboxaldehyde oxime 
• 133305-21-2 Pyrrole-2-(2-imino-1-phenylpropan-1-ol) 
• 1963-42-4 2-(p-methoxybenzyl)pyrrole 

Relevant articles and documents

Facile and Scalable Methodology for the Pyrrolo[2,1-f][1,2,4]triazine of Remdesivir

Pyrrolo[2,1-f][1,2,4]triazine (1) is an important regulatory starting material in the production of the antiviral drug remdesivir. Compound 1 was produced through a newly developed synthetic methodology utilizing simple building blocks such as pyrrole, chloramine, and formamidine acetate by examining the mechanistic pathway for the process optimization exercise. Triazine 1 was obtained in 55% overall yield in a two-vessel-operated process. This work describes the safety of the process, impurity profiles and control, and efforts toward the scale-up of triazine for the preparation of kilogram quantity.

Synthesis process of retegravir intermediate

The invention relates to a synthesis process of a retegravir intermediate 7-iodine-4-amido pyrrolo [2,1-F] [1, 2, 4] triazine. The method comprises the following steps: by using pyrrole as an initialraw material, carrying out aldehyde groupintroduction through phosphorus oxychloride-DMF to obtain 2-aldehyde group pyrrole; preparing a 2-cyano key intermediate through ammonium sulfate, wherein thesteps is the key step of the process; cyclizing the cyano intermediate and formamidine acetate to prepare a 4-amino intermediate; reacting with NIS and adding iodine to prepare the target compound 7-iodine-4-amido pyrrolo [2,1-F] [1, 2, 4] triazine. The whole process has the advantages of simple and easily available raw materials, simple and easy operation, and very high economic value and socialbenefit.

Investigating Alkylated Prodigiosenes and Their Cu(II)-Dependent Biological Activity: Interactions with DNA, Antimicrobial and Photoinduced Anticancer Activity

Prodigiosenes are a family of red pigments with versatile biological activity. Their tripyrrolic core structure has been modified many times in order to manipulate the spectrum of activity. We have been looking systematically at prodigiosenes substituted