254751-09-2

Basic information

• Product Name: Pentanoic acid, 4-oxo-3-[[(phenylmethoxy)carbonyl]amino]-5-(2,3,5,6-tetrafluorophenoxy )-, 1,1-dimethylethyl ester, (3S)-
• CAS NO: 254751-09-2
• Molecular Formula: C23H23F4NO6
• Molecular Weight: 485.432
• Mol File: 254751-09-2.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Pentanoic acid, 4-oxo-3-[[(phenylmethoxy)carbonyl]amino]-5-(2,3,5,6-tetrafluorophenoxy )-, 1,1-dimethylethyl ester, (3S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pentanoic acid, 4-oxo-3-[[(phenylmethoxy)carbonyl]amino]-5-(2,3,5,6-tetrafluorophenoxy )-, 1,1-dimethylethyl ester, (3S)-(254751-09-2)
• EPA Substance Registry System: Pentanoic acid, 4-oxo-3-[[(phenylmethoxy)carbonyl]amino]-5-(2,3,5,6-tetrafluorophenoxy )-, 1,1-dimethylethyl ester, (3S)-(254751-09-2)

Safety Data

• Hazardous Substances Data: 254751-09-2(Hazardous Substances Data)

Upstream product

• 41446-22-4 (S)-3-Benzyloxycarbonylamino-4-isobutoxycarbonyloxy-4-oxo-butyric acid tert-butyl ester 
• 769-39-1 2,3,5,6-tetraflourophenol 
• 153088-76-7 (S)-3-benzyloxycarbonylamino-5-bromo-4-oxo-pentanoic acid tert-butyl ester 
• 118248-02-5 Z-Asp(OBut)-CHN₂ 
• 5545-52-8 Z-D(tBu)-OH 

Relevant articles and documents

CASPASE INHIBITOR AND PHARMACEUTICAL COMPOSITION, USE AND THERAPEUTIC METHOD THEREOF

Disclosed are a class of compounds as a caspase inhibitor, and in particular the compound as shown in formula (I) or a pharmaceutically acceptable salt thereof, and the use of the compound in treating caspase-related diseases.

LINKED CYCLIC COMPOUND AS CASPASE INHIBITOR

A compound represented by formula (I), a pharmaceutically acceptable salt or tautomer thereof, and an application of the compound as a caspase inhibitor.

Synthesis and evaluation of indole aspartyl ketones as novel caspase-3 inhibitors

Synthesis, biological evaluation and structure-activity relationships for a series of novel nonpeptide small molecule inhibitors of caspase-3 are described. Among the synthesized compounds, 2,3,5,6-tetrafluorophenoxymethyl ketone derivatives of indole-N-a