254757-73-8

Basic information

• Product Name: (2S,5R)-6-Benzyloxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-5-hydroxy-hexanoic acid
• CAS NO: 254757-73-8
• Molecular Weight: 518.566
• Mol File: 254757-73-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2S,5R)-6-Benzyloxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-5-hydroxy-hexanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,5R)-6-Benzyloxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-5-hydroxy-hexanoic acid(254757-73-8)
• EPA Substance Registry System: (2S,5R)-6-Benzyloxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-5-hydroxy-hexanoic acid(254757-73-8)

Safety Data

• Hazardous Substances Data: 254757-73-8(Hazardous Substances Data)

Upstream product

• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 79432-14-7 (2S,5R)-2-amino-6-[(benzyloxycarbonyl)amino]-5-hydroxyhexanoic acid 

Downstream Products

• 254757-67-0 (5R)-N^α-[(fluoren-9-yl)methoxycarbonyl]-N^ε-benzyloxycarbonyl-5-hydroxy-L-lysine allyl ester 

Relevant articles and documents

9-BBN as a convenient protecting group in functionalisation of hydroxylysine

9-BBN was used for regioselective protection of the α-amino and α-carboxyl groups of (5R)-5-hydroxy-L-lysine. The resulting 9-BBN complex was then employed in transformations such as N-Cbz protection, azido transfer, O-glycosylation, and O-silylation. Further manipulations led to improved methods for preparation of hydroxylysine and galactosylated hydroxylysine building blocks, suitable for direct use in peptide synthesis under standard Fmoc conditions.