2549-30-6Relevant articles and documents
PDE10 MODULATORS
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Page/Page column 79, (2013/03/26)
The present invention relates to compounds of formula (I) wherein R1, R2, R3, R5, W, X, X1, Y, Y1, Z and Z1 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit PDE10A and can be used as medicaments.
Synthesis of 2,4,5-Trisubstituted Oxazoles
Cai, Xiao-hua,Yang, Hai-jun,Zhang, Guo-lin
, p. 1569 - 1571 (2007/10/03)
2,4,5-Trisubstituted oxazoles were synthesized in good yields starting from α-methylene ketones by nitrosation, condensation with aldehydes and reduction with zinc in acetic acid at 40 deg C. (5-Methyl-2-phenyloxazol-4-yl)ethanol was prepared by reduction of ethyl (5-methyl-2-phenyloxazol-4-yl)acetate with LiAlH4.