25561-30-2 Usage
Description
Bis(trimethylsilyl)trifluoroacetamide, also known as N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA), is a silyl ether derivative of trifluoroacetamide. It is a clear to yellowish liquid that serves as a derivatization agent used in gas chromatography/mass spectrometry (GC/MS) applications. BSTFA is known for its ability to react with various functional groups, making it a versatile compound in the field of chemistry.
Uses
Used in Pharmaceutical Synthesis:
Bis(trimethylsilyl)trifluoroacetamide is used as a reactant for the synthesis of pharmaceutical intermediates, contributing to the development of new drugs and medications.
Used in Antitumor Compound Preparation:
BSTFA is utilized as a reactant in the preparation of pyrimidinone ribosides and their analogs, which exhibit anti-tumor properties, potentially aiding in the fight against cancer.
Used in Analytical Chemistry:
In the field of analytical chemistry, BSTFA serves as a silylation reagent useful in GC and GC-MS for the derivatization of a wide range of functional groups under mild conditions. This makes it a valuable tool for various analytical purposes and the synthesis of more complex molecules.
Used as a Chemical Reagent:
Bis(trimethylsilyl)trifluoroacetamide is used as a chemical reagent for the synthesis of more complex molecules, thanks to its reactivity with various functional groups.
Used in Metabolomics Analysis:
BSTFA has been employed for metabolomics analysis of urine, specifically for the measurement of khatamines (psychoactive amines of khat, Catha edulis Forsk), and for the measurement of acrylamide in cocoa.
Used in Enzyme Inhibition:
Bis(trimethylsilyl)trifluoroacetamide is used as a DAT (dopamine transporter) inhibitor and a SLC6A2 (sodium-dependent neurotransmitter transporter) inhibitor, playing a role in the study and regulation of these proteins.
Used in Gas Chromatography and Mass Spectrometry:
BSTFA, in combination with trimethylchlorosilane, has found application in gas chromatography (GC) and mass-spectrometry (MS) for the analysis of various compounds.
Used in HPLC-Electrochemical Detection Assay:
Bis(trimethylsilyl)trifluoroacetamide is utilized in the HPLCelectrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine, which are relevant to DNA damage and repair mechanisms.
Check Digit Verification of cas no
The CAS Registry Mumber 25561-30-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,5,6 and 1 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 25561-30:
(7*2)+(6*5)+(5*5)+(4*6)+(3*1)+(2*3)+(1*0)=102
102 % 10 = 2
So 25561-30-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H18F3NOSi2/c1-14(2,3)8(9,15(4,5)6)7(13)12(10)11/h1-6H3
25561-30-2Relevant articles and documents
Carbacephalosporin compound, their preparation and use
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, (2008/06/13)
Carbacephalosporin compounds of formula (I), STR1 salts thereof, processes for their synthesis and uses thereof, wherein: R1 is hydrogen, methoxy or formamido; R2 is an acyl group; CO2 R3 is a carboxy group or a carboxylate anion, or R3 is a carboxy protecting group or a pharmaceutically acceptable salt-forming group or in vivo hydrolysable ester group; R4, R5, R6 and R7 represent hydrogen or a substituent; R4 and R7 may be replaced by a chemical bond between the two carbon atoms shown; R5 and R6 may be linked together into a cyclic system. The compounds (I) have antibacterial properties.
Bis-trimethylsilyl cefamandole and process therefor
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, (2008/06/13)
Bis-trimethylsilyl cefamandole is useful for regenerating cefamandole of excellent purity.
