256372-73-3Relevant articles and documents
Synthesis, crystal structure, and absolute configuration of the enantiomers of chiral drug xibenolol hydrochloride
Bredikhin, Alexander A.,Bredikhina, Zemfira A.,Kurenkov, Alexey V.,Gubaidullin, Aidar T.
, p. 1359 - 1366 (2017/11/09)
Based on the features of its crystallization, racemic 3-(2,3-dimethylphenoxy)propane-1,2-diol 2, the synthetic precursor of the chiral drug xibenolol 1, was resolved into pure enantiomers by the direct method of entrainment. The enantiomers of diol 2 thro
Asymmetric synthesis of aryloxypropanolamines via OsO4-catalyzed asymmetric dihydroxylation
Sayyed, Iliyas A.,Thakur, Vinay V.,Nikalje, Milind D.,Dewkar, Gajanan K.,Kotkar,Sudalai
, p. 2831 - 2838 (2007/10/03)
A simple and effective procedure for the enantioselective synthesis of several β-adrenergic blocking agents incorporating the first asymmetric synthesis of celiprolol, is described. The key steps are (i) sharpless asymmetric dihydroxylation of aryl allyl ethers to introduce chirality into the molecules and (ii) conversion of cyclic sulfates into the corresponding epoxides using a three-step procedure.