256427-40-4

Basic information

• Product Name: 20-chloro-20-deoxyingenol 3,5-dibenzoate
• Synonyms: 20-chloro-20-deoxyingenol 3,5-dibenzoate
• CAS NO: 256427-40-4
• Molecular Weight: 575.101
• Mol File: 256427-40-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 20-chloro-20-deoxyingenol 3,5-dibenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 20-chloro-20-deoxyingenol 3,5-dibenzoate(256427-40-4)
• EPA Substance Registry System: 20-chloro-20-deoxyingenol 3,5-dibenzoate(256427-40-4)

Safety Data

• Hazardous Substances Data: 256427-40-4(Hazardous Substances Data)

Upstream product

• 77495-85-3 ingenol 3,5-dibenzoate 
• 79720-52-8 ingenol 20-trityl ether 
• 30220-46-3 ingenol 

Relevant articles and documents

Synthesis of modified ingenol esters

Synthetic protocols for the manipulation of the polyhydroxylated southern region of ingenol (1a) were developed, and a series of isosteres of the anticancer compound ingenol 3,20-dibenzoate (1b) was prepared. The biological evaluation of these compounds showed that cytotoxicity was relatively tolerant to changes at C-20, while PKC activation was markedly affected by these modifications. These data suggest that chemical manipulation can effectively dissect cytotoxicity and tumour-promoting activity (or potential) of ingenoids, affording more optimal candidates for development, like 20-deoxy-20-fluoroingenol 3,20-dibenzoate (5b). In mild acidic medium, an unexpected vinylogous retro-pinacol rearrangement of ingenol to a tigliane derivative was observed.