77495-85-3

Basic information

• Product Name: (1aR)-5β,6β-Bis(benzoyloxy)-1aα,2,5,5a,6,9,10,10aα-octahydro-5aβ-hydroxy-4-(hydroxymethyl)-1,1,7,9α-tetramethyl-1H-2α,8aα-methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one
• Synonyms: (1aR)-5β,6β-Bis(benzoyloxy)-1aα,2,5,5a,6,9,10,10aα-octahydro-5aβ-hydroxy-4-(hydroxymethyl)-1,1,7,9α-tetramethyl-1H-2α,8aα-methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one
• CAS NO: 77495-85-3
• Molecular Formula: C₃₄H₃₆O₇
• Molecular Weight: 556.64544
• Mol File: 77495-85-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (1aR)-5β,6β-Bis(benzoyloxy)-1aα,2,5,5a,6,9,10,10aα-octahydro-5aβ-hydroxy-4-(hydroxymethyl)-1,1,7,9α-tetramethyl-1H-2α,8aα-methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one(CAS DataBase Reference)
• NIST Chemistry Reference: (1aR)-5β,6β-Bis(benzoyloxy)-1aα,2,5,5a,6,9,10,10aα-octahydro-5aβ-hydroxy-4-(hydroxymethyl)-1,1,7,9α-tetramethyl-1H-2α,8aα-methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one(77495-85-3)
• EPA Substance Registry System: (1aR)-5β,6β-Bis(benzoyloxy)-1aα,2,5,5a,6,9,10,10aα-octahydro-5aβ-hydroxy-4-(hydroxymethyl)-1,1,7,9α-tetramethyl-1H-2α,8aα-methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one(77495-85-3)

Safety Data

• Hazardous Substances Data: 77495-85-3(Hazardous Substances Data)

Upstream product

• 30220-46-3 ingenol 
• 79720-52-8 ingenol 20-trityl ether 

Downstream Products

• 59086-90-7 Ingenol dibenzoate 
• 256427-36-8 20-deoxy-20-fluoroingenol 3,5-dibenzoate 
• 256427-40-4 20-chloro-20-deoxyingenol 3,5-dibenzoate 

Relevant articles and documents

A convenient method for the preparation of 20-[18O]-labeled ingenol

A short and efficient protecting group-free synthesis of isotopically labeled 20-[18O]-ingenol has been developed. Based on a highly selective (only one out of four hydroxy groups) Mitsunobu reaction of ingenol with 18O2-acetic acid and subsequent methanolysis, this route yielded the desired 20-[18O]-ingenol in high yield and chemical and isotopic purity.