257933-82-7 Usage
Description
Pelitinib, also known as a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor, is a pharmaceutical compound with potential antineoplastic activity. It is characterized by its off-white solid appearance and functions by irreversibly inhibiting the EGFR receptor tyrosine kinase, as well as displaying weaker potency against HER2. By disrupting the Akt and MAPK pathways, pelitinib can induce apoptosis and suppress the growth of tumor cell lines, particularly showing strong efficacy against hepatocellular carcinoma cells.
Uses
Used in Anticancer Applications:
PELITINIB is used as an antineoplastic agent for its ability to inhibit the EGFR receptor tyrosine kinase and disrupt the Akt and MAPK pathways, leading to the suppression of tumor cell growth and the induction of apoptosis.
Used in Pharmaceutical Industry:
PELITINIB is used as an EGFR inhibitor for its potential in treating various types of cancer by targeting the epidermal growth factor receptor, which plays a crucial role in cell proliferation and survival.
Used in Cancer Treatment Formulation:
PELITINIB is used as a tyrosine kinase inhibitor in the preparation of formulations for treating primary or secondary cancer, particularly due to its strong efficacy against hepatocellular carcinoma cells.
references
[1] torrance cj, jackson pe, montgomery e, kinzler kw, vogelstein b, wissner a, nunes m, frost p, discafani cm. combinatorial chemoprevention of intestinal neoplasia. nat med. 2000 sep;6(9):1024-8.[2] nunes m, shi c, greenberger lm. phosphorylation of extracellular signal-regulated kinase 1 and 2, protein kinase b, and signal transducer and activator of transcription 3 are differently inhibited by an epidermal growth factor receptor inhibitor, ekb-569, in tumor cells and normal human keratinocytes. mol cancer ther. 2004 jan;3(1):21-7.
Check Digit Verification of cas no
The CAS Registry Mumber 257933-82-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,7,9,3 and 3 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 257933-82:
(8*2)+(7*5)+(6*7)+(5*9)+(4*3)+(3*3)+(2*8)+(1*2)=177
177 % 10 = 7
So 257933-82-7 is a valid CAS Registry Number.
InChI:InChI=1/C24H23ClFN5O2/c1-4-33-22-12-20-17(11-21(22)30-23(32)6-5-9-31(2)3)24(15(13-27)14-28-20)29-16-7-8-19(26)18(25)10-16/h5-8,10-12,14H,4,9H2,1-3H3,(H,28,29)(H,30,32)/b6-5+
257933-82-7Relevant articles and documents
USE OF CYANOQUINOLINES FOR TREATING OR INHIBITING COLONIC POLYPS
-
, (2008/06/13)
This invention provides a method of treating or inhibiting colonic polyps which comprises providing a compound of formula (1); wherein R1, R2, R3, R4, X, Y, and n are defined hereinbefore, or a pharmaceutically acceptable salt thereof.
Method of treating or inhibiting colonic polyps
-
, (2008/06/13)
This invention provides a method of treating or inhibiting colonic polyps which comprises providing a compound of formula 1 wherein:R1, R2, R3, R4, X, Y, and n are as defined hereinbefore, or a pharmaceutically acceptable salt thereof.