214476-08-1 Usage
Description
3-Cyano-7-ethoxy-4-hydroxy-6-nitroquinoline is an organic compound characterized by its brown solid appearance. It is a derivative of quinoline, a nitrogen-containing bicyclic compound, with a cyano group at the 3rd position, an ethoxy group at the 7th position, a hydroxy group at the 4th position, and a nitro group at the 6th position. 3-Cyano-7-ethoxy-4-hydroxy-6-nitroquinoline is known for its potential applications in the pharmaceutical industry, particularly in the development of antitumor agents.
Uses
Used in Pharmaceutical Industry:
3-Cyano-7-ethoxy-4-hydroxy-6-nitroquinoline is used as a reagent for the preparation of tyrosine kinase inhibiting antitumor agents. Tyrosine kinases are enzymes that play a crucial role in cell signaling, and their abnormal activity has been associated with various types of cancer. By inhibiting these enzymes, the compound can potentially help in the development of targeted therapies for cancer treatment.
The compound's unique structure and functional groups enable it to interact with tyrosine kinases, thereby disrupting their function and inhibiting the growth and progression of cancer cells. This makes 3-Cyano-7-ethoxy-4-hydroxy-6-nitroquinoline a valuable starting material for the synthesis of novel antitumor agents with potential applications in cancer research and drug development.
Check Digit Verification of cas no
The CAS Registry Mumber 214476-08-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,4,4,7 and 6 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 214476-08:
(8*2)+(7*1)+(6*4)+(5*4)+(4*7)+(3*6)+(2*0)+(1*8)=121
121 % 10 = 1
So 214476-08-1 is a valid CAS Registry Number.
InChI:InChI=1/C12H9N3O4/c1-2-19-11-4-9-8(3-10(11)15(17)18)12(16)7(5-13)6-14-9/h3-4,6H,2H2,1H3,(H,14,16)
214476-08-1Relevant articles and documents
NITROGENOUS HETEROCYCLIC COMPOUND, PREPARATION METHOD, INTERMEDIATE, COMPOSITION, AND APPLICATION
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Paragraph 0591; 0594, (2020/07/07)
A nitrogenous heterocyclic compound, a preparation method, an intermediate, a composition, and an application. The present invention provides a nitrogenous heterocyclic compound as represented by formula I, pharmaceutically acceptable salts thereof, enantiomers thereof, diastereoisomers thereof, tautomers thereof, solvates thereof, metabolites thereof, or prodrugs thereof. The compound has high inhibitory activity against ErbB2 tyrosine kinase, has good inhibitory activity against human breast cancer cells BT-474, human gastric cancer cells NCI-N87 and the like with high expression of ErbB2, and in addition has relatively weak inhibitory activity against EGFR kinase, that is, the compound is an EGFR/ErbB2 double target inhibitor that attenuates EGFR kinase inhibitory activity or a small-molecule inhibitor having selectivity for an ErbB2 target. (I)
Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors
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Page/Page column 54-55, (2008/12/07)
This invention provides compounds of formula 1 wherein R1, G1, G2, R4, Z, X and n are defined herein, or a pharmaceutically acceptable salt thereof, which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.
Process for the synthesis of 3-cyano-6-alkoxy-7-nitro-4-quinolones
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Page 4, (2010/02/08)
There is provided a process for the preparation of 3-cyano-6-alkoxy-7-nitro-4-quinolone intermediates useful for the preparation of protein tyrosine kinase (PTK) inhibitors which are useful in the treatment of cancer of the formula: wherein R is alkyl(Cs
