2585-30-0

Basic information

• Product Name: N-(4-chlorophenyl)-4-nitro-benzamide
• Synonyms: N-(4-chlorophenyl)-4-nitro-benzamide
• CAS NO: 2585-30-0
• Molecular Formula: C₁₃H₉ClN₂O₃
• Molecular Weight: 276.68
• Mol File: 2585-30-0.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 366.1°C at 760 mmHg
• Flash Point: 175.2°C
• Appearance: /
• Density: 1.44g/cm³
• Vapor Pressure: 1.5E-05mmHg at 25°C
• Refractive Index: 1.676
• CAS DataBase Reference: N-(4-chlorophenyl)-4-nitro-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-chlorophenyl)-4-nitro-benzamide(2585-30-0)
• EPA Substance Registry System: N-(4-chlorophenyl)-4-nitro-benzamide(2585-30-0)

Safety Data

• Hazardous Substances Data: 2585-30-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H9ClN2O3/c14-10-3-5-11(6-4-10)15-13(17)9-1-7-12(8-2-9)16(18)19/h1-8H,(H,15,17)

Upstream product

• 3460-11-5 4-nitrobenzanilide 
• 106-47-8 4-chloro-aniline 
• 122-04-3 4-nitro-benzoyl chloride 
• 59279-38-8 2,3,5-tri-O-(p-nitrobenzoyl)-β-D-ribofuranosyl bromide 
• 3128-43-6 S-phenyl 4-nitrobenzothioate 
• 6631-86-3 S-(p-chlorophenyl) p-nitrothiobenzoate 
• 28122-84-1 4-nitrothiobenzoic acid S-p-tolyl ester 
• 69737-96-8 S-(p-nitrophenyl) p-nitrothiobenzoate 
• 86399-76-0 N-(4-Chloro-phenyl)-4-nitro-N-(4-nitro-benzoyloxy)-benzamide 
• 62-23-7 4-nitro-benzoic acid 
• 619-50-1 4-nitrobenzoic acid methyl ester 
• 99-77-4 ethyl 4-nitrobenzoate 
• 637-87-6 1-Chloro-4-iodobenzene 
• 619-80-7 4-nitrobenzamide 

Downstream Products

• 861081-30-3 4-nitro-benzoic acid-(4-chloro-2,6-dinitro-anilide) 
• 32497-69-1 N-(4-Chloro-phenyl)-4-nitro-benzamidine 
• 99642-26-9 N-(4-chlorophenyl)-N-methyl-4-nitrobenzamide 
• 90234-26-7 N-methyl-4'-chloro-4-<(dimethylsulfamoyl)amino>benzanilide 
• 5388-62-5 4-chloro-2,6-dinitroaniline 
• 32497-70-4 4-Amino-N-(4-chloro-phenyl)-benzamidine 
• 32497-63-5 N-(4-Chloro-phenyl)-4-(N'-ethyl-guanidino)-benzamidine 
• 32502-91-3 N-(4-Chloro-phenyl)-4-(3-isopropyl-thioureido)-benzamidine 
• 32497-64-6 N-(4-Chloro-phenyl)-4-(N'-propyl-guanidino)-benzamidine 
• 32497-68-0 4-(N'-tert-Butyl-guanidino)-N-(4-chloro-phenyl)-benzamidine 
• 32497-66-8 N-(4-Chloro-phenyl)-4-(N'-isobutyl-guanidino)-benzamidine 
• 32497-65-7 4-(N'-Butyl-guanidino)-N-(4-chloro-phenyl)-benzamidine 
• 32497-67-9 4-(N'-sec-Butyl-guanidino)-N-(4-chloro-phenyl)-benzamidine 
• 955-97-5 4-amino-N-(4-chlorophenyl)benzamide 

Relevant articles and documents

Novel series of benzo[d]thiazolyl substituted-2-quinolone hybrids: Design, synthesis, biological evaluation and in-silico insights

A novel series of 3-(2-(4-(substituted-benzo[d]thiazol-2-yl)phenylamino)acetyl)-4?hydroxy-1-methyl/phenyl quinolin-2(1H)-one (7a-f and 8a-f) were synthesized. Reaction of appropriately substituted-2-(4-amino phenyl)benzo[d]thiazole (4a-f) with 3-(2-bromoacetyl)-4?hydroxy-1-methyl/phenyl quinolin-2(1H)-one (5/6) in the presence of glacial acetic acid resulted in desired compounds. Structures of the synthesized compounds were characterized based on their spectral (IR, 1H NMR, 13C NMR and MS) and elemental analysis. The cytotoxicity screening studies revealed that MCF-7 and WRL68 cancer cells were sensitive to all the tested compounds. Out of twelve novel hybrids, compound 8f displayed the most significant anticancer activity. Docking studies were performed in order to understand the binding mode of the title compounds at the active site of the target enzyme (EGFR tyrosine kinase, 1M17). Compounds 8f and 7f displayed prominent and conserved binding interactions against 1M17. In addition, compounds 7e, 7f, 8e, and 8f exhibited interesting in vitro antibacterial activity, especially against Gram-negative bacteria E. coli. In summary, the novel benzo[d]thiazolyl substituted-2-quinolone hybrid (8f) could be considered as promising hit and could be further exploited for developing potential anticancer/antimicrobial agents.

Green synthetic method of N-arylamides using recyclable cheap metal catalyst

Magnetically separable and reusable Fe/Cu oxide (Fe3O4-Cu2O) nanoparticles were employed as an efficient catalyst for the arylation of benzamide, which was carried out with a range of both arylboronic acid and benzamide to afford N-arylamide in good to excellent yield.

SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF

Provided herein are small molecule activators of Nicotinamide Phosphoribosyltransferase (NAMPT), compositions comprising the compounds, and methods of using the compounds and compositions.