99-77-4Relevant articles and documents
Further characterization of mitsunobu-type intermediates in the reaction of dialkyl azodicarboxylates with P(III) compounds
Kumara Swamy,Praveen Kumar,Bhuvan Kumar
, p. 1002 - 1008 (2006)
Structural characterization of compounds analogous to the proposed intermediates in the Mitsunobu esterification process is achieved by the combined use of NMR spectroscopy and X-ray diffractometric studies. The results show that compounds (t-BuNH)P(μ-N-t-Bu)2P[(N-t-Bu)(N-(CO 2R)-N(H)(CO2R))] [R = Et (11), i-Pr (12)], obtained by treating [(t-Bu-NH)P-μ-N-t-Bu]2 (10) with diethylazodicarboxylate (DEAD) or diisopropylazodicarboxylate (DIAD), respectively, have a structure with the NH proton residing between the two nitrogen atoms ((P)N(t-Bu) and (P)N-N(CO2Et)); this is the tautomeric form of the expected betaine (t-BuNH)P(μ-N-t-Bu)2P+[(NH-t-Bu)(N-(CO 2R)-N-(CO2R)]. Treatment of ClP(μ-N-t-Bu) 2P[(N-t-Bu){N-(CO2-i-Pr)-N(H)(CO2-i-Pr)] (6) with 2,6-dicholorophenol affords (2,6-Cl2-C6H 3-O)P-(μ-N-t-Bu)2P+[(NH-t-Bu){N[(CO 2i-Pr)(HNCO2i-Pr)]}](Cl-)(2,6-Cl 2-C6H3-OH) (14) that has a structure similar to that of (CF3CH2O)P(μ-N-t-Bu)2P +[(NH-t-Bu){N[(CO2i-Pr)(HNCO2i-Pr)]}](Cl -) (13), but with an additional hydrogen bonded phenol. Both of these have the protonated betaine structure analogous to that of Ph3P +N(CO2R)NH(CO2R)(R′CO2) - (2) proposed in the Mitsunobu esterification. Two other compounds, (ArO)P(μ-N-t-Bu)2P+(NH-t-Bu){N(CO2i-Pr) (HNCO2i-Pr)}(Cl-) [Ar = 2,6-Me2C 6H3O- (15) and 2-Me-6-t-Bu-C6H3-O- (16)], are also prepared by the same route. Although NMR tube reactions of 11 or 12 with tetrachlorocatechol, catechol, 2,2′-biphenol, and phenol revealed significant changes in the 31P NMR spectra, attempted isolation of these products was not successful. On the basis of 31P NMR spectra, the phosphonium salt structure (t-BuNH)P(μ-N-t-Bu)2P +[(HN-t-Bu){N-(CO2R)-N(H)(CO2R)]-(ArO -) is proposed for these. The weakly acidic propan-2-ol or water did not react with 11 or 12, Treatment of 12 with carboxylic acids/p-toluenesulfonic acid gave the products (t-BuNH)P(μ-N-t-Bu)2P+[(HN-t- Bu){N-(CO2-i-Pr)-N(H)(CO2-i-Pr)](ArCO2-) [Ar = Ph (18), 4-Cl-C6H4CH2 (19), 4-Br-C 6H4 (20), 4-NO2-C6H4 (21)] and (t-BuNH)P(μ-N-t-Bu)2P+|(HN-t-Bu){N-(CO 2-i-Pr)-N(H)(CO2-i-Pr)](4-CH3-C 6H4SO3-) (22) that have essentially the same structure as 2. Compound 18 has additional stabilization by hydrogen bonding, as revealed by X-ray structure determination. Finally it is shown that the in situ generated (t-BuNH)P(μ-N-t-Bu)2P+[(HN-t-Bu) {N-(CO2Et)-N(H)(CO2Et)](4-NO2-C 6H4CO2-) can also effect Mitsunobu esterification. A comparison of the Ph3P-DIAD system with the analogous synthetically useful Ph3P-dimethyl acetylenedicarboxylate (DMAD) system is made.
The polyhedral nature of selenium-catalysed reactions: Se(iv) species instead of Se(vi) species make the difference in the on water selenium-mediated oxidation of arylamines
Capperucci, Antonella,Dalia, Camilla,Tanini, Damiano
supporting information, p. 5680 - 5686 (2021/08/16)
Selenium-catalysed oxidations are highly sought after in organic synthesis and biology. Herein, we report our studies on the on water selenium mediated oxidation of anilines. In the presence of diphenyl diselenide or benzeneseleninic acid, anilines react with hydrogen peroxide, providing direct and selective access to nitroarenes. On the other hand, the use of selenium dioxide or sodium selenite leads to azoxyarenes. Careful mechanistic analysis and 77Se NMR studies revealed that only Se(iv) species, such as benzeneperoxyseleninic acid, are the active oxidants involved in the catalytic cycle operating in water and leading to nitroarenes. While other selenium-catalysed oxidations occurring in organic solvents have been recently demonstrated to proceed through Se(vi) key intermediates, the on water oxidation of anilines to nitroarenes does not. These findings shed new light on the multifaceted nature of organoselenium-catalysed transformations and open new directions to exploit selenium-based catalysis.
Using m icrowave and ultrasound to synthesis of substituted bis-acyl hydrazone derivatives
Mohammed, Salim J.,Sheat, Attallah M.,A.abood, Salih,Yahya, Omar M.
, p. 6423 - 6427 (2021/11/01)
In this paper, some new bis-acyl hydrazone derivatives (4a-f) were prepared through the reaction of carboxylic acid hydrazides with 1,4-diacetylbenzene using classical methods, microwave and ultrasound irradiation methods. These compounds are obtained through a series of reactions where some carboxylic acids react with ethanol first in the presence of concentrated sulfuric acid to give the corresponding esters (2a-f), which when treatment with aqueous hydrazine give carboxylic acid hydrazides (3a-f).thus, The results proved that the use of microwave and ultrasound techniques is much better than the classical methods, as it gave a higher yield, shorter reaction time, and the absence of the use of solvents. All newly synthesized compounds were confirmed by IR, (1H & 13C) NMR spectral analysis and the corresponding reactions were monitored by TLC using the reported eluent.