25983-54-4

Basic information

• Product Name: Benzaldehyde, 2-hydroxy-6-(phenylmethoxy)-
• CAS NO: 25983-54-4
• Molecular Formula: C14H12O3
• Molecular Weight: 228.247
• Mol File: 25983-54-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 2-hydroxy-6-(phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 2-hydroxy-6-(phenylmethoxy)-(25983-54-4)
• EPA Substance Registry System: Benzaldehyde, 2-hydroxy-6-(phenylmethoxy)-(25983-54-4)

Safety Data

• Hazardous Substances Data: 25983-54-4(Hazardous Substances Data)

Upstream product

• 760210-73-9 5-(benzyloxy)-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one 
• 154714-19-9 5-hydroxy-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one 
• 100-39-0 benzyl bromide 
• 25983-51-1 2,6-bis(benzyloxy)benzoic acid methyl ester 
• 25983-52-2 2,6-dibenzyloxybenzyl alcohol 
• 2150-45-0 methyl 2,6-dihydroxybenzoate 
• 71752-89-1 2-(benzyloxy)-6-hydroxybenzoic acid 
• 25983-53-3 3-((3-(benzyloxy)-2-formylphenoxy)methyl)benzene 

Downstream Products

• 25983-55-5 Methyl 3-benzyloxy-2-formylphenoxyacetat 
• 101451-61-0 1-(4-(benzyloxy)benzofuran-2-yl)ethanone 

Relevant articles and documents

Discovery of Potent Protease-Activated Receptor 4 Antagonists with in Vivo Antithrombotic Efficacy

In an effort to identify novel antithrombotics, we have investigated protease-activated receptor 4 (PAR4) antagonism by developing and evaluating a tool compound, UDM-001651, in a monkey thrombosis model. Beginning with a high-throughput screening hit, we identified an imidazothiadiazole-based PAR4 antagonist chemotype. Detailed structure-activity relationship studies enabled optimization to a potent, selective, and orally bioavailable PAR4 antagonist, UDM-001651. UDM-001651 was evaluated in a monkey thrombosis model and shown to have robust antithrombotic efficacy and no prolongation of kidney bleeding time. This combination of excellent efficacy and safety margin strongly validates PAR4 antagonism as a promising antithrombotic mechanism.

Efficient and selective reduction protocols of the 2,2-dimethyl-1,3- benzodioxan-4-one functional group to readily provide both substituted salicylaldehydes and 2-hydroxybenzyl alcohols

Two complementary procedures have been developed that selectively allow for the synthesis of either substituted salicylaldehydes or the corresponding 2-hydroxylbenzyl alcohols upon treatment of the 2,2-dimethyl-1,3-benzodioxan-4- one functional group with DIBAL-H or LAH, respectively.

Coumarins. XI. A total synthesis of (plus-minus)-Columbianetin.

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